Brain response to calorie restriction

被引:49
作者
Fusco, Salvatore [1 ]
Pani, Giovambattista [1 ]
机构
[1] Catholic Univ, Sch Med, Inst Gen Pathol, Lab Cell Signaling, Rome, Italy
关键词
Calorie restriction; Brain ageing; Nutrient sensing; CREB; Stem cell; Neurodegenerative disease; HEMATOPOIETIC STEM-CELLS; GENE-EXPRESSION PROFILE; LONG-TERM-MEMORY; SYNAPTIC PLASTICITY; ENERGY-BALANCE; DIETARY RESTRICTION; ALZHEIMERS-DISEASE; AGRP NEURONS; LIFE-SPAN; NEURODEGENERATIVE DISEASES;
D O I
10.1007/s00018-012-1223-y
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Calorie restriction extends longevity and delays ageing in model organisms and mammals, opposing the onset and progression of an array of age-related diseases. These beneficial effects also extend to the maintenance of brain cognitive functions at later age and to the prevention, at least in rodents, of brain senescence and associated neurodegenerative disorders. In recent years, the molecular mechanisms underlying brain response to calorie restriction have begun to be elucidated, revealing the unanticipated role of a number of key nutrient sensors and nutrient-triggered signaling cascades in the translation of metabolic cues into cellular and molecular events that ultimately lead to increased cell resistance to stress, enhanced synaptic plasticity, and improved cognitive performance. Of note, the brain's role in CR also includes the activation of nutrient-sensitive hypothalamic circuitries and the implementation of neuroendocrine responses that impact the entire organism. The present review addresses emerging molecular themes in brain response to dietary restriction, and the implications of this knowledge for the understanding and the prevention of brain disorders associated with ageing and metabolic disease.
引用
收藏
页码:3157 / 3170
页数:14
相关论文
共 169 条
[1]   Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability [J].
Adams, Michelle M. ;
Shi, Lei ;
Linville, M. Constance ;
Forbes, M. Elizabeth ;
Long, Ashley B. ;
Bennett, Colleen ;
Newton, Isabel G. ;
Carter, Christy S. ;
Sonntag, William E. ;
Riddle, David R. ;
Brunso-Bechtold, Judy K. .
EXPERIMENTAL NEUROLOGY, 2008, 211 (01) :141-149
[2]   The Creb1 coactivator Crtc1 is required for energy balance and fertility [J].
Altarejos, Judith Y. ;
Goebel, Naomi ;
Conkright, Michael D. ;
Inotiel, Hiroshi ;
Xie, Jianxin ;
Arias, Carlos M. ;
Sawchenko, Paul E. ;
Montminy, Marc .
NATURE MEDICINE, 2008, 14 (10) :1112-1117
[3]   CREB and the CRTC co-activators: sensors for hormonal and metabolic signals [J].
Altarejos, Judith Y. ;
Montminy, Marc .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2011, 12 (03) :141-151
[4]   ATP-sensitive K+ channels and insulin secretion:: their role in health and disease [J].
Ashcroft, FM ;
Gribble, FM .
DIABETOLOGIA, 1999, 42 (08) :903-919
[5]   Crosstalk between Components of Circadian and Metabolic Cycles in Mammals [J].
Asher, Gad ;
Schibler, Ueli .
CELL METABOLISM, 2011, 13 (02) :125-137
[6]   Impairments of Synaptic Plasticity in Aged Animals and in Animal Models of Alzheimer's Disease [J].
Balietti, Marta ;
Tamagnini, Francesco ;
Fattoretti, Patrizia ;
Burattini, Costanza ;
Casoli, Tiziana ;
Platano, Daniela ;
Lattanzio, Fabrizia ;
Aicardi, Giorgio .
REJUVENATION RESEARCH, 2012, 15 (02) :235-238
[7]   Blood-brain barrier and energy balance [J].
Banks, William A. .
OBESITY, 2006, 14 :234-237
[8]   Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat [J].
Barzilai, N ;
Banerjee, S ;
Hawkins, M ;
Chen, W ;
Rossetti, L .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (07) :1353-1361
[9]   Redox regulation of cAMP-responsive element-binding protein and induction of manganous superoxide dismutase in nerve growth factor-dependent cell survival [J].
Bedogni, B ;
Pani, G ;
Colavitti, R ;
Riccio, A ;
Borrello, S ;
Murphy, M ;
Smith, R ;
Eboli, ML ;
Galeotti, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) :16510-16519
[10]   Hormone and glucose signalling in POMC and AgRP neurons [J].
Belgardt, Bengt F. ;
Okamura, Tomoo ;
Bruening, Jens C. .
JOURNAL OF PHYSIOLOGY-LONDON, 2009, 587 (22) :5305-5314