Synthesis of Stilbene Derivatives: A Comparative Study of their Antioxidant Activities

被引：0
作者：
Romero, Miguel A. [1 ,2 ]
Gonzalez-Delgado, Jose A. [1 ,2 ]
Arteaga, Jesus F. [1 ,2 ]
机构：
[1] Univ Huelva, CIQSO Ctr Res Sustainable Chem, Huelva 21071, Spain
[2] Univ Huelva, Dept Chem Engn Phys Chem & Organ Chem, Huelva 21071, Spain
来源：
NATURAL PRODUCT COMMUNICATIONS | 2015年 / 10卷 / 07期
关键词：
Antioxidant activity; Stilbene; Synthesis; Electrochemical assays; RADICAL CATIONS; RESVERATROL; ANALOGS; DEOXYGENATION; GENERATION; REACTIVITY; OXIDATION; HYDROXYL; BIBENZYL; CANCER;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of structurally simple compounds belonging to thestilbene family were synthesized by means of a Ti(III)-mediated methodology that allows access, in an efficient manner, to derivatives of dihydrostilbene, E-stilbene, and stilbene oxide, with high yields. The antioxidant activity of these compounds has been evaluated by means of two electrochemical assays, which provide complementary information, showing that the majority of these stilbene analogs exhibit significant antioxidant activity dependent on the electronic structure and functionalization of the molecule in each case.
引用
收藏
页码：1257 / 1262
页数：6
相关论文
共 48 条
  • [1] Biological activity of resveratrol, a stilbenic compound from grapevines, against Botrytis cinerea, the causal agent for gray mold
    Adrian, M
    Jeandet, P
    Veneau, J
    Weston, LA
    Bessis, R
    [J]. JOURNAL OF CHEMICAL ECOLOGY, 1997, 23 (07) : 1689 - 1702
  • [2] Adrian M, 2006, OXIDAT STRESS DIS, V20, P475
  • [3] Resveratrol - A boon for treating Alzheimer's disease?
    Anekonda, Thimmappa S.
    [J]. BRAIN RESEARCH REVIEWS, 2006, 52 (02) : 316 - 326
  • [4] Antolovich M, 2002, ANALYST, V127, P183, DOI 10.1039/b009171p
  • [5] Comparison of the Simple Cyclic Voltammetry (CV) and DPPH Assays for the Determination of Antioxidant Capacity of Active Principles
    Arteaga, Jesus F.
    Ruiz-Montoya, Mercedes
    Palma, Alberto
    Alonso-Garrido, Gema
    Pintado, Sara
    Rodriguez-Mellado, Jose M.
    [J]. MOLECULES, 2012, 17 (05): : 5126 - 5138
  • [6] Resveratrol: A review of preclinical studies for human cancer prevention
    Athar, Mohammad
    Back, Jung Ho
    Tang, Xmwel
    Kim, Kwang Ho
    Kopelovich, Levy
    Bickers, David R.
    Kim, Arianna L.
    [J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 2007, 224 (03) : 274 - 283
  • [7] Reductive coupling of terpenic allylic halides catalyzed by CP2TiCl:: A short and efficient asymmetric synthesis of onocerane triterpenes
    Barrero, AF
    Herrador, MM
    del Moral, JFQ
    Arteaga, P
    Arteaga, JF
    Piedra, M
    Sánchez, EM
    [J]. ORGANIC LETTERS, 2005, 7 (12) : 2301 - 2304
  • [8] Couplings of benzylic halides mediated by titanocene chloride:: Synthesis of bibenzyl derivatives
    Barrero, Alejandro F.
    Herrador, M. Mar
    Quilez del Moral, Jose F.
    Arteaga, Pilar
    Akssira, Mohammed
    El Hanbali, Fadwa
    Arteaga, Jesus F.
    Dieguez, Horacio R.
    Sanchez, Elena M.
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2007, 72 (06) : 2251 - 2254
  • [9] Total Synthesis of the Marine Metabolite (±)-Polysiphenol via Highly Regioselective Intramolecular Oxidative Coupling
    Barrett, Tim N.
    Braddock, D. Christopher
    Monta, Anna
    Webb, Michael R.
    White, Andrew J. P.
    [J]. JOURNAL OF NATURAL PRODUCTS, 2011, 74 (09): : 1980 - 1984
  • [10] Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: Significance of the para-hydroxyl orientation
    Baskin, Rebekah
    Gali, Meghanath
    Park, Sung O.
    Zhao, Zhizhuang Joe
    Keseru, Gyoergy M.
    Bisht, Kirpal S.
    Sayeski, Peter P.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (03) : 1402 - 1407
12345