Heritability and stability of resting blood pressure in Australian twins

被引：12
作者：
Hottenga, JJ
Whitfield, JB
de Geus, EJC
Boomsma, DI
Martin, NG
机构：
[1] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Ctr Neurogenom & Clin Res, Amsterdam, Netherlands
[3] Queensland Inst Med Res, Genet Epidemiol Lab, Brisbane, Qld 4006, Australia
来源：
TWIN RESEARCH AND HUMAN GENETICS | 2006年 / 9卷 / 02期
关键词：
D O I：
10.1375/twin.9.2.205
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In Australian twins participating in three different studies (1979-1996), the contribution of genetic and environmental influences to variation in resting systolic (SBP) and diastolic blood pressure (DBP) was studied. The sample consisted of 368 monozygotic and 335 dizygotic twin pairs with measurements for both individuals. Blood pressure measurements in two studies were available for 115 complete twin pairs, and 49 twin pairs had measurements in three studies. This allowed assessment of blood pressure tracking over an average period of 12 years in the age range of 23 to 45 years. Multivariate analyses showed significant heritability (h(2)) of blood pressure in all studies (SBP h(2) = 19%-56%, DBP h(2) = 37%-52%). In addition, the analyses showed that the blood pressure tracking was explained by the same set of genetic factors. These results replicate an earlier finding in Dutch twins that also showed stability of the contribution of genetic factors to blood pressure tracking.
引用
收藏
页码：205 / 209
页数：5
相关论文
共 18 条
[1]   Covariance components models for longitudinal family data [J].
Burton, PR ;
Scurrah, KJ ;
Tobin, MD ;
Palmer, LJ .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2005, 34 (05) :1063-1077
[2]   A GENETIC AND ENVIRONMENTAL TIME-SERIES ANALYSIS OF BLOOD-PRESSURE IN MALE TWINS [J].
COLLETTO, GMDD ;
CARDON, LR ;
FULKER, DW .
GENETIC EPIDEMIOLOGY, 1993, 10 (06) :533-538
[3]   Antihypertensive treatments obscure familial contributions to blood pressure variation [J].
Cui, JSS ;
Hopper, JL ;
Harrap, SB .
HYPERTENSION, 2003, 41 (02) :207-210
[4]   Stability of variables associated with the metabolic syndrome from adolescence to adulthood: The Aerobics Center Longitudinal Study [J].
Eisenmann, JC ;
Welk, GJ ;
Wickel, EE ;
Blair, SN .
AMERICAN JOURNAL OF HUMAN BIOLOGY, 2004, 16 (06) :690-696
[5]   The genetics of coronary heart disease: The contribution of twin studies [J].
Evans, A ;
van Baal, GCM ;
McCarron, P ;
deLange, M ;
Soerensen, TIA ;
de Geus, EJC ;
Kyvik, K ;
Pedersen, NL ;
Spector, TD ;
Andrew, T ;
Patterson, C ;
Whitfield, JB ;
Zhu, G ;
Martin, NG ;
Kaprio, J ;
Boomsma, DI .
TWIN RESEARCH, 2003, 6 (05) :432-441
[6]   Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men [J].
Heath, AC ;
Bucholz, KK ;
Madden, PAF ;
Dinwiddie, SH ;
Slutske, WS ;
Bierut, LJ ;
Statham, DJ ;
Dunne, MP ;
Whitfield, JB ;
Martin, NG .
PSYCHOLOGICAL MEDICINE, 1997, 27 (06) :1381-1396
[7]   Heritability and stability of resting blood pressure [J].
Hottenga, JJ ;
Boomsma, DI ;
Kupper, N ;
Posthuma, D ;
Snieder, H ;
Willemsen, G ;
de Geus, EJC .
TWIN RESEARCH AND HUMAN GENETICS, 2005, 8 (05) :499-508
[8]   Repeated blood pressure measurements in a sample of Swedish twins: heritabilities and associations with polymorphisms in the renin-angiotensin-aldosterone system [J].
Iliadou, A ;
Lichtenstein, P ;
Morgenstern, R ;
Forsberg, L ;
Svensson, R ;
de Faire, U ;
Martin, NG ;
Pedersen, NL .
JOURNAL OF HYPERTENSION, 2002, 20 (08) :1543-1550
[9]   Large-scale search for genes predisposing to essential hypertension [J].
Lalouel, JM .
AMERICAN JOURNAL OF HYPERTENSION, 2003, 16 (02) :163-166
[10]   A TWIN STUDY OF ETHANOL-METABOLISM [J].
MARTIN, NG ;
PERL, J ;
OAKESHOTT, JG ;
GIBSON, JB ;
STARMER, GA ;
WILKS, AV .
BEHAVIOR GENETICS, 1985, 15 (02) :93-109
12