A chromatin structure-based model accurately predicts DNA replication timing in human cells

被引：64

作者：

Gindin, Yevgeniy ^{[1
,2
]}

Valenzuela, Manuel S. ^{[3
]}

Aladjem, Mirit I. ^{[4
]}

Meltzer, Paul S. ^{[1
]}

Bilke, Sven ^{[1
]}

机构：

[1] Ctr Canc Res, Genet Branch, Bethesda, MD USA

[2] Boston Univ, Grad Program Bioinformat, Boston, MA 02215 USA

[3] Meharry Med Coll, Sch Med, Dept Biochem & Canc Biol, Nashville, TN 37208 USA

[4] NCI, Mol Pharmacol Lab, Bethesda, MD 20892 USA

来源：

MOLECULAR SYSTEMS BIOLOGY | 2014年 / 10卷 / 03期

关键词：

DNA replication timing; computational model; DNase hypersensitivity; systems analysis; GENOME-SCALE ANALYSIS; REVEALS; TRANSLOCATION; INITIATION; ORIGINS; FUSION;

D O I：

10.1002/msb.134859

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A mechanistic model predicts cell lineage-specific DNA replication timing based on the location of DNase-hypersensitivity data alone. With essentially no parameters to adjust for different cell types, the model is truly predictive even for cells where timing data are not available.image

引用

页数：11

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