Targeting the host hemostatic system function in bacterial infection for antimicrobial therapies

被引：2
作者：
Xu, Yuanxi [1 ]
Yu, Haiqing [1 ]
Sun, Hongmin [1 ,2 ]
机构：
[1] Univ Missouri Hosp & Clin, Dept Internal Med, Columbia, MO USA
[2] Univ Missouri, Div Cardiovasc Med, Columbia, MO 65212 USA
来源：
JOURNAL OF THROMBOSIS AND THROMBOLYSIS | 2014年 / 37卷 / 01期
关键词：
Infection; Hemostatic factor; Platelet; Antimicrobial therapy; ACTIVATED PROTEIN-C; NF-KAPPA-B; STAPHYLOCOCCUS-AUREUS; INFLAMMATORY RESPONSE; TISSUE FACTOR; RICH PLASMA; CONTACT SYSTEM; GROWTH-FACTORS; PLASMINOGEN; PLATELETS;
D O I：
10.1007/s11239-013-0994-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The hemostatic system is an important player in host's response to infection. It has been shown that host hemostatic factors as well as platelets, interact with various proteins from bacteria and play important roles in host defense against infections. This review summarizes studies of function of host hemostatic system in host defense against bacterial infections and efforts to target hemostatic system interaction with pathogens to develop potential antimicrobial therapies.
引用
收藏
页码：66 / 73
页数：8
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