Anti-Helicobacter pylori potential of Agrimonia eupatoria L. and Fragaria vesca

被引：23

作者：

Cardoso, Olga ^{[1
,2
]}

Donato, Maria Manuel ^{[3
]}

Luxo, Cristina ^{[1
,2
]}

Almeida, Nuno ^{[4
,5
]}

Liberal, Joana ^{[6
]}

Figueirinha, Artur ^{[7
,8
]}

Batista, Maria Teresa ^{[2
,7
]}

机构：

[1] Univ Coimbra, Lab Microbiol, Fac Pharm, P-3000548 Coimbra, Portugal

[2] Univ Coimbra, Dept Chem Engn, CIEPQPF, Fac Sci & Technol, P-3030790 Coimbra, Portugal

[3] Univ Coimbra, CIMAGO, Fac Med, P-3000548 Coimbra, Portugal

[4] Univ Coimbra, Fac Med, P-3000548 Coimbra, Portugal

[5] Ctr Hosp & Univ Coimbra, Gastroenterol Dept, P-3004531 Coimbra, Portugal

[6] Inst Politecn Castelo Branco, Escola Super Saude Lopes Dias, P-6000767 Castelo Branco, Portugal

[7] Univ Coimbra, Lab Pharmacognosy, Fac Pharm, P-3000548 Coimbra, Portugal

[8] Univ Coimbra, LAQV, Fac Pharm, REQUIMTE, P-3000548 Coimbra, Portugal

来源：

JOURNAL OF FUNCTIONAL FOODS | 2018年 / 44卷

关键词：

Helicobacter pylori; Fragaria vesca; Agrimonia eupatoria; Ellagitannins; Activity; MEDICINAL-PLANTS; CENTRAL REGION; RESISTANCE;

D O I：

10.1016/j.jff.2018.03.027

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Helicobacter pylori (H. pylon) plays a causal role in chronic gastritis, peptic ulcer and gastric cancer. Antibiotic resistance and side effects of therapy have led to research for new candidates. Susceptibility and virulence factors were studied in H. pylon 12 clinical isolates. Agrimonia eupatoria L. (Ag), Fragaria vesca (Fv) extracts and a Fv ellagitannin-enriched fraction (Fve) activity were tested against these isolates. Ag, Fv extracts and Fve presented activity against H. pylon multi-resistant and virulent. Fve demonstrated the best activity (5 mg/mL inhibited 67% of isolates), follow by Fv (12.5 mg/mL inhibited 58%) and by Ag (25 mg/mL inhibited 40%). This is the first report of Fv extract and Fve fraction activity on H. pylori isolates. These activity and that of Ag were independently of the different patterns of virulence and susceptibility, suggesting potential of these plants as new natural drugs or as bioactive agents in association with antibiotic therapy.

引用

页码：299 / 303

页数：5

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