Discovery and optimization of inhibitors of the KIFC1 motor protein.

被引:0
|
作者
Lamb, Michelle L. [1 ]
Wu, Jiaquan [1 ]
Mikule, Keith [1 ]
Wang, Wendy [1 ]
Su, Nancy [1 ]
Petteruti, Philip [1 ]
Gharahdaghi, Farzin [1 ]
Code, Erin [1 ]
Zhu, Xiahui [1 ]
Jacques, Kelly [1 ]
Lai, Zhongwu [1 ]
Zhang, Tao [1 ]
Boulay, David [1 ]
Grewal, Gurmit [1 ]
Keen, Nicholas [1 ]
Yang, Bin [1 ]
Chuaqui, Claudio [1 ]
Chuaqui, Claudio [1 ]
Chen, Huawei [1 ]
机构
[1] AstraZeneca Pharmaceut LP, Waltham, MA USA
关键词
D O I
10.1158/1535-7163.TARG-13-C55
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
C55
引用
收藏
页数:1
相关论文
共 50 条
  • [31] KIFC1 is a novel potential therapeutic target for breast cancer
    Li, Yonghe
    Lu, Wenyan
    Chen, Dongquan
    Boohaker, Rebecca J.
    Zhai, Ling
    Padmalayam, Indira
    Wennerberg, Krister
    Xu, Bo
    Zhang, Wei
    CANCER BIOLOGY & THERAPY, 2015, 16 (09) : 1316 - 1322
  • [32] High Expression of KIFC1 in Glioma Correlates with Poor Prognosis
    Xue, Pengfei
    Zheng, Juan
    Li, Rongrong
    Yan, Lili
    Wang, Zhaohao
    Jia, Qingbin
    Zhang, Lianqun
    Li, Xin
    JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, 2024, 67 (03) : 364 - 375
  • [33] Evaluation of centrosome clustering protein KIFC1 as a potential prognostic biomarker in serous ovarian adenocarcinomas.
    Mittal, Karuna
    Choi, Da Hoon
    Klimov, Sergey
    Pawar, Shrikant
    Kaur, Ramneet
    Mitra, Anirban
    Gupta, Meenakshi Vij
    Sams, Ralph
    Cantuaria, Guilherme
    Rida, Padmashree C. G.
    Aneja, Ritu
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [34] The Roles of KIFC1 in the Development of Osteosarcoma: Characterization of Potential Therapeutic Targets
    Liang, Li-Yan
    Li, Gui-Shi
    Computational and Mathematical Methods in Medicine, 2022, 2022
  • [35] The Roles of KIFC1 in the Development of Osteosarcoma: Characterization of Potential Therapeutic Targets
    Liang, Li-Yan
    Li, Gui-Shi
    COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2022, 2022
  • [36] C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma
    Xiao, Yu-Xi
    Shen, Hao-Qing
    She, Zhen-Yu
    Sheng, Li
    Chen, Qian-Qian
    Chu, Yu-Lan
    Tan, Fu-Qing
    Yang, Wan-Xi
    ONCOTARGET, 2017, 8 (37) : 61373 - 61384
  • [37] Identification of KIFC1 as a putative vulnerability in lung cancers with centrosome amplification
    Zhang, Christopher
    Wu, Benson Z.
    Di Ciano-Oliveira, Caterina
    Wu, Yin Fang
    Binstock, Sharon S. Khavkine
    Soria-Bretones, Isabel
    Pham, Nhu-An
    Elia, Andrew J.
    Chari, Raj
    Lam, Wan L.
    Bray, Mark R.
    Mak, Tak W.
    Tsao, Ming-Sound
    Cescon, David W.
    Thu, Kelsie L.
    CANCER GENE THERAPY, 2024, 31 (10) : 1559 - 1570
  • [38] KIFC1 in cancer: Understanding its expression, regulation, and therapeutic potential
    Sanghvi, Gaurav
    Roopashree, R.
    Kashyap, Aditya
    Sabarivani, A.
    Ray, Subhashree
    Bhakuni, Pushpa Negi
    EXPERIMENTAL CELL RESEARCH, 2025, 447 (01)
  • [39] Potential role of kinesin family member C1 (KIFC1) in melanoma
    Mau, Davis S.
    Ndiaye, Mary A.
    Zaemisch, Gabriella R.
    Singh, Chandra K.
    Vera, Jess
    McIlwain, Sean R.
    Ahmad, Nihal
    CANCER RESEARCH, 2023, 83 (08)
  • [40] Kinesin KIFC1 actively transports bare double-stranded DNA
    Farina, F.
    Pierobon, P.
    Delevoye, C.
    Monnet, J.
    Dingli, F.
    Loew, D.
    Quanz, M.
    Dutreix, M.
    Cappello, G.
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2013, 42 : S60 - S60