Evidence of recombination in a new isolate of foot-and-mouth disease virus serotype Asia 1

被引：25

作者：

Lee, Kwang-Nyeong ^{[1
,3
]}

Oem, Jae-Ku ^{[1
]}

Park, Jong-Hyeon ^{[1
]}

Kim, Su-Mi ^{[1
]}

Lee, Seo-Yong ^{[1
]}

Tserendorj, Sh. ^{[2
]}

Sodnomdarjaa, R. ^{[2
]}

Joo, Yi-Seok ^{[1
]}

Kim, Heebal ^{[3
]}

机构：

[1] Natl Vet Res & Quarantine Serv, Foreign Anim Dis Div, Anyang 430824, Gyeonggi, South Korea

[2] States Cent Vet Lab, Ulaanbaatar 210153, Mongolia

[3] Seoul Natl Univ, Coll Agr & Life Sci, Dept Agr Biotechnol, Seoul 151742, South Korea

来源：

VIRUS RESEARCH | 2009年 / 139卷 / 01期

关键词：

Foot-and-mouth disease; Asia; 1; Recombination; 2C; Mongolia; China; SECRETORY PATHWAY; SOFTWARE; SEQUENCE; PROTEIN; GENOMES; STRAIN; 2BC; 2C;

D O I：

10.1016/j.virusres.2008.09.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Phylogenetic analysis of the nucleotide sequence of VP1 revealed that a new isolate of foot-and-mouth disease virus (FMDV) serotype Asia 1 identified in Mongolia in 2005 was related to Chinese and Russian strains isolated during the same year. In this study, these strains were defined as East Asian strains having a common geographical origin, and the complete genomic sequence of the Mongolian strain (As1/MOG/05) was determined and compared to other strains of serotype Asia 1. As1/MOG/05 showed 100% identity with an East Asian strain from China (As1/Qinghai/CHA/05) in terms of its VP1 nucleotide sequence. However, the Mongolian strain has a four-amino acid extension in 3D that is missing from all other strains of serotype Asia 1, and which is not due to an insertion. A full genomic scan revealed that the Mongolian strain is closer to the East Asian strain As1/JS/CHA/05 than to all other strains of serotype Asia 1 in nearly all genomic regions. Within the narrow region of low similarity between the two sequences, As1/JS/CHA/05 was found to have a mosaic structure with a partial 2C fragment supposedly transferred from Hong Kong strain As1/HNK/CHA/05. The genomic mosaicism and extension detected in non-structural protein-coding regions in this study may be used to trace the origins and evolution of problematic strains of serotype Asia I that have arisen in East Asia since 2005. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：117 / 121

页数：5

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