Conquering Cancer Multi-Drug Resistance Using Curcumin and Cisplatin Prodrug-Encapsulated Mesoporous Silica Nanoparticles for Synergistic Chemo- and Photodynamic Therapies

被引:13
作者
Busa, Prabhakar [1 ]
Kankala, Ranjith Kumar [1 ,2 ]
Deng, Jin-Pei [3 ]
Liu, Chen-Lun [1 ]
Lee, Chia-Hung [1 ]
机构
[1] Natl Dong Hwa Univ, Dept Life Sci, Hualien 97401, Taiwan
[2] Huaqiao Univ, Coll Chem Engn, Xiamen 361021, Peoples R China
[3] Tamkang Univ, Dept Chem, New Taipei 251, Taiwan
关键词
photodynamic therapy; p-glycoprotein; Cisplatin; mesoporous silica nanoparticles; reactive oxygen species; COMBINATION THERAPY; DRUG-DELIVERY; ABC-TRANSPORTERS; CO-DELIVERY; CHEMOTHERAPY; STRATEGIES; PHARMACOKINETICS; MECHANISMS; TUMOR;
D O I
10.3390/nano12203693
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Recently, the development of anti-cancer approaches using different physical or chemical pathways has shifted from monotherapy to synergistic therapy, which can enhance therapeutic effects. As a result, enormous efforts have been devoted to developing various delivery systems encapsulated with dual agents for synergistic effects and to combat cancer cells acquired drug resistance. In this study, we show how to make Institute of Bioengineering and Nanotechnology (IBN)-1-based mesoporous silica nanoparticles (MSNs) for multifunctional drug delivery to overcome drug resistance cancer therapy. Initially, curcumin (Cur)-embedded IBN-1 nanocomposites (IBN-1-Cur) are synthesized in a simple one-pot co-condensation and then immobilized with the prodrug of Cisplatin (CP) on the carboxylate-modified surface (IBN-1-Cur-CP) to achieve photodynamic therapy (PDT) and chemotherapy in one platform, respectively, in the fight against multidrug resistance (MDR) of MES-SA/DX5 cancer cells. The Pluronic F127 triblock copolymer, as the structure-directing agent, in nanoparticles acts as a p-glycoprotein (p-gp) inhibitor. These designed hybrid nanocomposites with excellent structural properties are efficiently internalized by the endocytosis and successfully deliver Cur and CP molecules into the cytosol. Furthermore, the presence of Cur photosensitizer in the nanochannels of MSNs resulted in increased levels of cellular reactive oxygen species (ROS) under light irradiation. Thus, IBN-1-Cur-CP showed excellent anti-cancer therapy in the face of MES-SA/DX5 resistance cancer cells, owing to the synergistic effects of chemo- and photodynamic treatment.
引用
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页数:19
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