Serum 90K/Mac-2 Binding Protein (Mac-2BP) as a Response Predictor to Peginterferon and Ribavirin Combined Treatment in Hcv Chronic Patients

被引：1

作者：

Iacovazzi, Palma A. ^{[1
]}

Cozzolongo, Raffaele ^{[1
]}

Lanzillotta, Elsa ^{[1
]}

Frisullo, Stefania ^{[1
]}

Guerra, Vito ^{[1
]}

Correale, Mario ^{[1
]}

机构：

[1] Natl Inst Gastroenterol, Bari, Italy

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2008年 / 30卷 / 04期

关键词：

90K/Mac-2BP; Hepatitis C; Treatment;

D O I：

10.1080/08923970802278177

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

90K/Mac-2BP glycoprotein is involved in the immune defense against a variety of neoplasms and viral infections, modulating the activity of several effectors such as natural killer cells. Quite interestingly, 90K/Mac-2BP is associated to a poor response to interferon (IFN) alpha in hepatitis C virus (HCV) infected patients. Here, in 70 consecutive HCV chronic patients, we have evaluated 90K basal levels as a response predictor to combined therapy with Peginterferon and Ribavirin. We have found higher 90K levels in genotype 1/4 than in genotype 2/3 (p = 0.006) and in 62.5% of non-responders than in 20% of responders (p < 0.001). Genotype 1/4, higher 90K and gamma glutamyl transferase (gamma GT) levels resulted independently associated to a status of refractoriness to therapy. Consequently, evaluation of 90K serum levels seems to be a promising useful marker of response to combined therapy in HCV disease.

引用

页码：687 / 700

页数：14