Neonatal Host Defense against Staphylococcal Infections

被引：26
作者：
Coombs, Melanie R. Power [1 ]
Kronforst, Kenny [2 ,3 ]
Levy, Ofer [4 ,5 ]
机构：
[1] Dalhousie Univ, Halifax, NS B3H 4R2, Canada
[2] Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA
[3] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
[4] Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA
[5] Harvard Univ, Sch Med, Human Biol & Translat Med, Boston, MA USA
来源：
CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2013年
基金：
比尔及梅琳达.盖茨基金会; 美国国家卫生研究院;
关键词：
BIRTH-WEIGHT INFANTS; TOLL-LIKE RECEPTORS; COAGULASE-NEGATIVE STAPHYLOCOCCI; COLONY-STIMULATING FACTOR; NECROSIS-FACTOR-ALPHA; INNATE IMMUNITY; BLOOD-STREAM; IN-VITRO; ANTIMICROBIAL PROTEINS; INFLAMMATORY RESPONSE;
D O I：
10.1155/2013/826303
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Preterm infants are especially susceptible to late-onset sepsis that is often due to Gram-positive bacterial infections resulting in substantial morbidity and mortality. Herein, we will describe neonatal innate immunity to Staphylococcus spp. comparing differences between preterm and full-term newborns with adults. Newborn innate immunity is distinct demonstrating diminished skin integrity, impaired Th1-polarizing responses, low complement levels, and diminished expression of plasma antimicrobial proteins and peptides, especially in preterm newborns. Characterization of distinct aspects of the neonatal immune response is defining novel approaches to enhance host defense to prevent and/or treat staphylococcal infection in this vulnerable population.
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页数：9
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