Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines

被引：68
作者：
Chen, Yiyin [1 ]
Angelova, Angelina [2 ]
Angelov, Borislav [3 ]
Drechsler, Markus [4 ]
Garamus, Vasil M. [5 ]
Willumeit-Roemer, Regine [5 ]
Zou, Aihua [1 ]
机构：
[1] E China Univ Sci & Technol, Shanghai 200237, Peoples R China
[2] Univ Paris 11, LabEx LERMIT, Inst Galien Paris Sud, CNRS,UMR8612, F-92296 Chatenay Malabry, France
[3] Acad Sci Czech Republ, Inst Macromol Chem, CR-16206 Prague, Czech Republic
[4] Univ Bayreuth, Bayreuth Inst Macromol Res BIMF, Lab Soft Matter Electron Microscopy, D-95440 Bayreuth, Germany
[5] Helmholtz Zentrum Geesthacht, Ctr Mat & Coastal Res, D-21502 Geesthacht, Germany
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2015年 / 3卷 / 39期
基金：
中国国家自然科学基金;
关键词：
LIQUID-CRYSTALLINE NANOPARTICLES; SURFACE PRESSURE MEASUREMENTS; SYNCHROTRON-RADIATION SAXS; LANGMUIR-BLODGETT SYSTEMS; TARGETED CO-DELIVERY; INDUCED LIVER-INJURY; BRUCEA [!text type='JAVA']JAVA[!/text]NICA OIL; IN-VITRO; SUSTAINED-RELEASE; DRUG-DELIVERY;
D O I：
10.1039/c5tb01193k
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Multidrug delivery devices are designed to take advantage of the synergistic effects of anticancer agents in combination therapies. Here we report novel liquid crystalline self-assembled nanocarriers enhancing the activity of the phytochemical anticancer agent baicalin (BAI) in combination with Brucea javanica oil (BJO), which ensures safe formulations for clinical applications. Small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) evidenced the multicompartment, sponge-type nano-organization of the blank and multidrug-loaded liquid crystalline carriers. Physico-chemical stability of the sponge nanoparticles was achieved through PEGylation of the lipid membranes, which make up the drug nanocarriers. The proposed green nanotechnology for nanocarrier preparation by supramolecular self-assembly provided a multidrug encapsulation efficiency as high as 75%. The apoptosis study with the human lung carcinoma cell line A549 demonstrated improved efficacy of the multidrug delivery nanocarriers in comparison to the single-drug reservoirs. The obtained results evidenced the synergistic anticancer apoptotic effects of the multidrug-loaded nanosponge carriers and suggested the opportunity for in vivo translation towards the treatment of lung, gastrointestinal, and ovarian cancers.
引用
收藏
页码：7734 / 7744
页数：11
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