Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines

被引：68

作者：

Chen, Yiyin ^{[1
]}

Angelova, Angelina ^{[2
]}

Angelov, Borislav ^{[3
]}

Drechsler, Markus ^{[4
]}

Garamus, Vasil M. ^{[5
]}

Willumeit-Roemer, Regine ^{[5
]}

Zou, Aihua ^{[1
]}

机构：

[1] E China Univ Sci & Technol, Shanghai 200237, Peoples R China

[2] Univ Paris 11, LabEx LERMIT, Inst Galien Paris Sud, CNRS,UMR8612, F-92296 Chatenay Malabry, France

[3] Acad Sci Czech Republ, Inst Macromol Chem, CR-16206 Prague, Czech Republic

[4] Univ Bayreuth, Bayreuth Inst Macromol Res BIMF, Lab Soft Matter Electron Microscopy, D-95440 Bayreuth, Germany

[5] Helmholtz Zentrum Geesthacht, Ctr Mat & Coastal Res, D-21502 Geesthacht, Germany

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2015年 / 3卷 / 39期

基金：

中国国家自然科学基金;

关键词：

LIQUID-CRYSTALLINE NANOPARTICLES; SURFACE PRESSURE MEASUREMENTS; SYNCHROTRON-RADIATION SAXS; LANGMUIR-BLODGETT SYSTEMS; TARGETED CO-DELIVERY; INDUCED LIVER-INJURY; BRUCEA [!text type='JAVA']JAVA[!/text]NICA OIL; IN-VITRO; SUSTAINED-RELEASE; DRUG-DELIVERY;

D O I：

10.1039/c5tb01193k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Multidrug delivery devices are designed to take advantage of the synergistic effects of anticancer agents in combination therapies. Here we report novel liquid crystalline self-assembled nanocarriers enhancing the activity of the phytochemical anticancer agent baicalin (BAI) in combination with Brucea javanica oil (BJO), which ensures safe formulations for clinical applications. Small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) evidenced the multicompartment, sponge-type nano-organization of the blank and multidrug-loaded liquid crystalline carriers. Physico-chemical stability of the sponge nanoparticles was achieved through PEGylation of the lipid membranes, which make up the drug nanocarriers. The proposed green nanotechnology for nanocarrier preparation by supramolecular self-assembly provided a multidrug encapsulation efficiency as high as 75%. The apoptosis study with the human lung carcinoma cell line A549 demonstrated improved efficacy of the multidrug delivery nanocarriers in comparison to the single-drug reservoirs. The obtained results evidenced the synergistic anticancer apoptotic effects of the multidrug-loaded nanosponge carriers and suggested the opportunity for in vivo translation towards the treatment of lung, gastrointestinal, and ovarian cancers.

引用

页码：7734 / 7744

页数：11

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