Takotsubo Cardiomyopathy Do the Genetics Matter?

被引：20

作者：

Limongelli, Giuseppe ^{[1
]}

D'Alessandro, Raffaella ^{[2
]}

Masarone, Daniele ^{[1
]}

Maddaloni, Valeria ^{[2
]}

Vriz, Olga ^{[3
]}

Minisini, Rosalba ^{[4
]}

Citro, Rodolfo ^{[5
]}

Calabro, Paolo ^{[1
]}

Russo, Maria Giovanna ^{[1
]}

Calabro, Raffaele ^{[1
]}

Pacileo, Giuseppe ^{[1
]}

Bossone, Eduardo ^{[6
,7
]}

Elliott, Perry Mark ^{[8
]}

机构：

[1] Univ Naples 2, Monaldi Hosp, AO Colli, Cardiol SUN, I-80100 Naples, Italy

[2] Univ Naples 2, Monaldi Hosp, Genom & Cellular Lab, I-80100 Naples, Italy

[3] Osped San Antonio, Dept Cardiol & Emergency, I-33038 Udine, Italy

[4] Univ Eastern Piedmont Amedeo Avogadro, Dept Translat Med, I-28100 Novara, Italy

[5] Univ Hosp San Giovanni Dio & Ruggi Aragona, Heart Dept, Salerno, Italy

[6] Univ Salerno, Cava de Tirreni & Amalfi Coast Hosp, Heart Dept, Div Cardiol, Tirreni, SA, Italy

[7] IRCCS Policlin San Donato, Dept Cardiac Surg, I-20097 San Donato Milanese, Milanese, Italy

[8] UCL, Heart Hosp, Inherited Cardiac Dis Unit, London W1H 8PH, England

来源：

HEART FAILURE CLINICS | 2013年 / 9卷 / 02期

关键词：

Takotsubo cardiomyopathy; Genetics; Adrenoceptor polymorphisms; TAKO-TSUBO CARDIOMYOPATHY; LONG-QT SYNDROME; FRAGILE-X-SYNDROME; STRESS CARDIOMYOPATHY; ABNORMALITIES; POLYMORPHISM; DYSFUNCTION; FEATURES; PATIENT;

D O I：

10.1016/j.hfc.2012.12.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Takotsubo Cardiomyopathy: Do the Genetics Matter? Giuseppe Limongelli, Raffaella D'Alessandro, Daniele Masarone, Valeria Maddaloni, Olga Vriz, Rosalba Minisini, Rodolfo Citro, Paolo Calabro, Maria Giovanna Russo, Raffaele Calabro, Giuseppe Pacileo, Eduardo Bossone, and Perry Mark Elliott Takotsubo cardiomyopathy (TTC) is an enigmatic disease with a multifactorial and still unresolved pathogenesis. Recent experimental and clinical observation has suggested a role for genetics in the pathogenesis of TTC. Ethnic as well as seasonal variation in the prevalence of TTC is well described, but it is only recently that familial cases of TTC have been reported. In recent years technological advances in exome capture and DNA sequencing have offered clinicians a new opportunity to discover genetics-related disease. This article explores the role of genetic mechanisms that might explain or modulate the pathogenesis of TTC.

引用

页码：207 / +

页数：11

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