Control of multiple arthropod vector infestations with subolesin/akirin vaccines

被引:81
作者
Moreno-Cid, Juan A. [1 ]
Perez de la Lastra, Jose M. [1 ]
Villar, Margarita [1 ]
Jimenez, Maribel [2 ]
Pinal, Rocio [3 ]
Estrada-Pena, Agustin [4 ]
Molina, Ricardo [2 ]
Lucientes, Javier [3 ]
Gortazar, Christian [1 ]
de la Fuente, Jose [1 ,5 ]
机构
[1] Inst Invest Recursos Cineget IREC CSIC UCLM JCCM, Ciudad Real 13005, Spain
[2] Inst Salud Carlos III, Ctr Nacl Microbiol, Serv Parasitol, Unidad Entomol Med, Madrid 28220, Spain
[3] Fac Vet, Dept Patol Anim, Zaragoza 50013, Spain
[4] Fac Vet, Dept Parasitol, Zaragoza 50013, Spain
[5] Oklahoma State Univ, Ctr Vet Hlth Sci, Dept Vet Pathobiol, Stillwater, OK 74078 USA
关键词
Akirin; Arthropod; Mosquito; Sand fly; Subolesin; Tick; Vaccine; Immunology; ANOPHELES-STEPHENSI DIPTERA; TICK PROTECTIVE ANTIGEN; ANAPLASMA-MARGINALE; BOOPHILUS-MICROPLUS; PATHOGEN INFECTION; VACCINATION; MOSQUITO; GENE; EXPRESSION; CATTLE;
D O I
10.1016/j.vaccine.2012.12.073
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Diseases transmitted by arthropod vectors such as mosquitoes, ticks and sand flies greatly impact human and animal health and thus their control is important for the eradication of vector-borne diseases (VBD). Vaccination is an environmentally friendly alternative for vector control that allows control of several VBD by targeting their common vector. Recent results have suggested that subolesin/akirin (SUB/AKR) is good candidate antigens for the control of arthropod vector infestations. Here we describe the comparative effect of vaccination with SUB, AKR and Q38 and Q41 chimeras containing SUB/AKR conserved protective epitopes on tick, mosquitoes and sand flies vector mortality, molting, oviposition and/or fertility. We demonstrated that SUB vaccination had the highest efficacy (E) across all vector species (54-92%), Q41 vaccination had the highest vaccine E in mosquitoes (99%) by reducing female survival and fertility, and Q38 vaccination had the highest effect on reducing mosquito (28%) and sand fly (26%) oviposition. The effect of vaccination on different developmental processes in several important arthropod vectors encourages the development of SUB/AKR universal vaccines for the control of multiple vector infestations and reduction of VBD. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1187 / 1196
页数:10
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