A high-resolution map around the locus Om on mouse Chromosome 11

被引：23
作者：
Baldacci, PA
CohenTannoudji, M
Kress, C
Pournin, S
Babinet, C
机构：
[1] U. de Biol. du Devmt., U.R.A.C.N.R.S. 1960, Institut Pasteur, Paris 75724 Cedex 15
来源：
MAMMALIAN GENOME | 1996年 / 7卷 / 02期
关键词：
D O I：
10.1007/s003359900030
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The locus Om (ovum mutant) identified in the mouse strain DDK affects the viability of (DDK x non-DDK)F-1 preimplantation embryos. We previously located this locus on Chromosome (Chr) 11 close to Scya2 (Baldacci et al. Mamm. Genome 2, 100-105, 1992). Here we report a high-resolution map of the region around Om based on a large number of backcross individuals. The same region has been analyzed on the EUCIB backcross, and the two maps have been compared. The results define the proximal and distal boundaries for the Om mutation as Scya2 and D11Mit36 respectively. The distance between these two markers is about 2 cM. These data should facilitate the positional cloning and molecular characterization of Om.
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页码：114 / 116
页数：3
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