Effectiveness of Laparoscopic Total and Partial Fundoplication on Extraesophageal Manifestations of Gastroesophageal Reflux Disease: A Randomized Study

被引：33

作者：

Koch, Oliver O. ^{[1
]}

Antoniou, Stavros A. ^{[2
]}

Kaindlstorfer, Adolf ^{[1
]}

Asche, Kai U. ^{[1
]}

Granderath, Frank A. ^{[2
]}

Pointner, Rudolph ^{[1
]}

机构：

[1] Gen Hosp Zell See, Dept Gen Surg, A-5700 Zell Am See, Austria

[2] Neuwerk Hosp, Dept Gen & Visceral Surg, Monchengladbach, Germany

来源：

SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES | 2012年 / 22卷 / 05期

关键词：

GERD; hoarseness; chronic cough; reflux-induced asthma; NISSEN FUNDOPLICATION; NORMAL VALUES; IMPEDANCE; COUGH;

D O I：

10.1097/SLE.0b013e31825efb5b

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The aim of the present study was to evaluate the clinical effect of partial and total fundoplication on extraesophageal symptoms in a selected cohort of patients with gastroesophageal reflux disease (GERD). Hundred patients with documented GERD were randomized to either undergo floppy Nissen (n=50) or Toupet fundoplication (n=50). Symptom scores of cough, asthma, hoarseness, and distortion of taste were prospectively evaluated using a standardized symptom questionnaire before surgery and at 3- and 12-month follow-up. Statistical significance was set at a P-value of 0.05. All evaluated symptoms exhibited substantial improvement after Nissen fundoplication at 3- and 12-month follow-up. Similar therapeutic results were documented for Toupet fundoplication, although statistical significance could not be reached for asthma at long-term follow-up. In conclusion, the application of laparoscopic fundoplication is justified for patients with documented GERD and atypical symptoms refractory to medical treatment. Toupet fundoplication may have a lesser effect on asthma.

引用

页码：387 / 391

页数：5

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