THE SYNTHESIS OF NEW 5-AMINOISOXAZOLES BY REACTION OF THIOCARBAMOYLCYANOACETATES WITH HYDROXYLAMINE

被引:9
作者
Khalafy, J. [1 ]
Dilmaghani, K. Akbari [1 ]
Soltani, L. [1 ]
Poursattar-Marjani, A. [1 ]
机构
[1] Urmia Univ, Fac Sci, Dept Chem, Orumiyeh 57154, Iran
关键词
hydroxylamine; isothiocyanates; isoxazoles; thioxopropanoates;
D O I
10.1007/s10593-008-0101-x
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The reaction of thiocarbamoylcyanoacetates with hydroxylamine in ethanol under reflux conditions has provided a convenient method for the synthesis of 5-aminoisoxazoles.
引用
收藏
页码:729 / 734
页数:6
相关论文
共 50 条
[31]   SYNTHESIS AND X-RAY STRUCTURE OF NEW 5-AMINO-METHYL-4-ISOXAZOLECARBOXYLIC ACID AZIDES [J].
RYNG, S ;
MACHON, Z ;
GLOWIAK, T .
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 1994, 24 (08) :483-488
[32]   Efficient synthesis of novel 1-hydroxy-2,4,5-trisubstituted imidazole derivatives via a one-pot, four-component reaction between hydroxylamine, benzonitriles, arylglyoxals and cyclic 1,3-dicarbonyl compounds [J].
Alizadeh-Bami, Farzaneh ;
Salehzadeh, Mina ;
Mehrabi, Hossein ;
Ranjbar-Karimi, Reza .
ARKIVOC, 2019, :55-63
[33]   Boric acid-catalyzed multi-component reaction for efficient synthesis of 4H-isoxazol-5-ones in aqueous medium [J].
Kiyani, Hamzeh ;
Ghorbani, Fatemeh .
RESEARCH ON CHEMICAL INTERMEDIATES, 2015, 41 (05) :2653-2664
[34]   Synthesis and characterization of new homologous series of unsymmetrical liquid crystalline compounds based on chalcones and 3, 5-disubstituted isoxazoles [J].
Sowmya, P. T. ;
Rai, K. M. Lokanatha .
JOURNAL OF CHEMICAL SCIENCES, 2017, 129 (01) :67-73
[35]   Synthesis and characterization of new homologous series of unsymmetrical liquid crystalline compounds based on chalcones and 3, 5-disubstituted isoxazoles [J].
SOWMYA P T ;
K M LOKANATHA RAI .
Journal of Chemical Sciences, 2017, 129 :67-73
[36]   Synthesis and structure-activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists [J].
Budzik, Brian W. ;
Evans, Karen A. ;
Wisnoski, David D. ;
Jin, Jian ;
Rivero, Ralph A. ;
Szewczyk, George R. ;
Jayawickreme, Channa ;
Moncol, David L. ;
Yu, Hongshi .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (04) :1363-1367
[37]   Synthesis, immunomodulating effects and structure-activity relationships of new N-phenyl-5-amino-3-methylisoxazole-4-carboxamides [J].
Ryng, S ;
Machon, Z ;
Wieczorek, Z ;
Zimecki, M ;
Mokrosz, M .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1998, 33 (10) :831-836
[38]   Synthesis and X-ray characterisation of a new polycondensed heterocycle obtained by a novel Mn(III) -mediated cascade reaction of 2-cyanophenyl isothiocyanate [J].
Calestani, G ;
Capella, L ;
Leardini, R ;
Minozzi, M ;
Nanni, D ;
Papa, R ;
Zanardi, G .
TETRAHEDRON, 2001, 57 (33) :7221-7233
[39]   SYNTHESIS AND ASSESSMENT OF BIOLOGICAL ACTIVITY OF SOME NEW CHALCONES, AMINO PYRIMIDINES AND ISOXAZOLES DERIVATIVES INCORPORATING 1, 3, 5-TRIAZINE MOIETY [J].
Bhavna, Shah ;
Nisha, Pandey .
HETEROCYCLIC LETTERS, 2020, 10 (03) :447-457
[40]   Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective [J].
Abadi, Ashraf H. ;
Gary, Bernard D. ;
Tinsley, Heather N. ;
Piazza, Gary A. ;
Abdel-Halim, Mohammad .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (04) :1278-1286