A facile one-pot, three-component synthesis of 3,3′-(4-arylpyridine-2,6-diyl)bis(2H-chromen-2-one) derivatives under microwave irradiation

被引：6
作者：
Zhou, Jian-Feng [1 ]
Sun, Xiao-Jun [1 ]
Lou, Feng-Wen [1 ]
Lv, Meng [2 ]
Zhang, Lu-Lu [2 ]
机构：
[1] Huaiyin Normal Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Chem Low Dimens Mat, Huaian 223300, Peoples R China
[2] Ningxia Univ, Sch Chem & Chem Engn, Yinchuan 750021, Peoples R China
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2013年 / 39卷 / 03期
关键词：
3,3 '-(4-Arylpyridine-2,6-diyl)bis(2H-chromen-2-one); 3-Acetylcoumarin; Multicomponent reaction; Microwave irradiation; TOPOISOMERASE-I INHIBITION; SUBSTITUTED PYRIDINES; TRYPANOSOMA-CRUZI; CYTOTOXICITY; COMPLEXES;
D O I：
10.1007/s11164-012-0696-5
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 3,3'-(4-arylpyridine-2,6-diyl)bis(2H-chromen-2-one) derivatives have been synthesized by the one-pot, three-component reaction of 3-acetylcoumarin, an aromatic aldehyde, and ammonium acetate in acetic acid under microwave irradiation. This procedure has the major advantages of short reaction time, good yields, low energy consumption, easy operation, and environmental friendliness. All of the products were characterized by IR and NMR spectroscopy, MS, and elemental analysis.
引用
收藏
页码：1401 / 1408
页数：8
相关论文
共 20 条
  • [1] Cytotoxicity, antioxidant, and antimicrobial activities of novel 2-quinolone derivatives derived from coumarin
    Al-Amiery, Ahmed A.
    Al-Bayati, Redha I. H.
    Saour, Kawkab Y.
    Radi, Mahdi F.
    [J]. RESEARCH ON CHEMICAL INTERMEDIATES, 2012, 38 (02) : 559 - 569
  • [2] BALASUBRAMANIAN M, 1996, COMPREHENSIVE HETE 2, V5
  • [3] (2,2′:6′,2"-terpyridine)platinum(II) complexes are irreversible inhibitors of Trypanosoma cruzi trypanothione reductase but not of human glutathione reductase
    Bonse, S
    Richards, JM
    Ross, SA
    Lowe, G
    Krauth-Siegel, RL
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (25) : 4812 - 4821
  • [4] Pharmacophore-Based discovery of substituted Pyridines as novel dopamine transporter inhibitors
    Enyedy, IJ
    Sakamuri, S
    Zaman, WA
    Johnson, KM
    Wang, SM
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (03) : 513 - 517
  • [5] Catalyst-Free Synthesis of α,α-bis(4-Hydroxycoumarin-3-yl)toluene in Aqueous Media Under Microwave Irradiation
    Gong, Gui-Xia
    Zhou, Jian-Feng
    An, Li-Tao
    Duan, Xiu-Li
    Ji, Shun-Jun
    [J]. SYNTHETIC COMMUNICATIONS, 2009, 39 (03) : 497 - 505
  • [6] Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione
    Kim, BY
    Ahn, JB
    Lee, HW
    Kang, SK
    Lee, JH
    Shin, JS
    Ahn, SK
    Hong, CI
    Yoon, SS
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2004, 39 (05) : 433 - 447
  • [7] New pyridine derivatives as potential antimicrobial agents
    Klimesová, V
    Svoboda, M
    Waisser, K
    Pour, M
    Kaustová, J
    [J]. FARMACO, 1999, 54 (10): : 666 - 672
  • [8] A novel and facile synthesis of 7,8-diacylcoumarins
    Kotali, Antigoni
    Lafazanis, Ioannis S.
    Harris, Philip A.
    [J]. TETRAHEDRON LETTERS, 2007, 48 (40) : 7181 - 7183
  • [9] Cytotoxicity of (2,2′:6′,2"terpyridine) platinum(II) complexes to Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei
    Lowe, G
    Droz, AS
    Vilaivan, T
    Weaver, GW
    Tweedale, L
    Pratt, JM
    Rock, P
    Yardley, V
    Croft, SL
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (06) : 999 - 1006
  • [10] OKennedy R.D.T. Richard, 1997, Coumarins: biology, applications and mode of action, V1st
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