Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function

被引：47
作者：
Brand, Marjorie [1 ,2 ]
Nakka, Kiran [1 ,2 ]
Zhu, Jiayu [1 ,2 ]
Dilworth, F. Jeffrey [1 ,2 ]
机构：
[1] Ottawa Hosp Res Inst, Sprott Ctr Stem Cell Res, Ottawa, ON K1H 8L6, Canada
[2] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1H 8L6, Canada
来源：
CELL STEM CELL | 2019年 / 24卷 / 04期
关键词：
REPRESSIVE COMPLEX 1; H3; LYSINE; 27; CHROMATIN REMODELING COMPLEXES; EZH2 SUPPRESSES METHYLATION; METHYLTRANSFERASE GENE EZH2; GROUP PROTEIN EZH2; HISTONE H3; SELF-RENEWAL; TRANSCRIPTION FACTORS; DEVELOPMENTAL REGULATORS;
D O I：
10.1016/j.stem.2019.03.005
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Stem cells are continuously challenged with the decision to either self-renew or adopt a new fate. Self-renewal is regulated by a system of cellular memory, which must be bypassed for differentiation. Previous studies have identified Polycomb group (PcG) and Trithorax group (TrxG) proteins as key modulators of cellular memory. In this Perspective, we draw from embryonic and adult stem cell studies to discuss the complex roles played by PcG and TrxG in maintaining cell identity while allowing for microenvironment-mediated alterations in cell fate. Finally, we discuss the potential for targeting these proteins as a therapeutic approach in cancer.
引用
收藏
页码：518 / 533
页数：16
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