A Novel and Efficient One Pot Synthesis of 2,4-Disubstituted Thiazoles and Oxazoles Using Phenyltrimethylammoniumtribromide in Ionic Liquid

被引：15
|
作者：
Muthyala, Manoj Kumar [1 ]
Kumar, Anil [1 ]
机构：
[1] Birla Inst Technol & Sci, Dept Chem, Pilani 333031, Rajasthan, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2012年 / 49卷 / 04期
关键词：
MICROWAVE IRRADIATION; 2-AMINOTHIAZOLES; AMINOTHIAZOLES; YB(OTF)(3); INHIBITORS; IMIDAZOLE; ALKALOIDS; CATALYST; ANALOGS; AGENTS;
D O I：
10.1002/jhet.904
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and efficient one-pot procedure has been described for synthesis of 2,4-disubstituted thiazoles and oxazoles from substituted ketones using phenyltrimethylammoniumtribromide as in situ brominating agent followed by reaction with thioamide/thiourea and amides/ureas, respectively in [bmim][BF4] ionicliquid. The advantages of the procedure include avoiding the handling of lacrymetric compounds, hazardous and toxic organic solvents along with good to excellent yield of the products.
引用
收藏
页码：959 / 964
页数：6
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