Resveratrol Role in Autoimmune DiseaseA Mini-Review

被引：94

作者：

de Brito Oliveira, Ana Ligia ^{[1
]}

Silva Monteiro, Valter Vinicius ^{[2
]}

Navegantes-Lima, Kely Campos ^{[1
]}

Reis, Jordano Ferreira ^{[2
]}

Gomes, Rafaelli de Souza ^{[1
]}

Silva Rodrigues, Davila Valentina ^{[2
]}

de Franca Gaspar, Silvia Leticia ^{[2
]}

Monteiro, Marta Chagas ^{[1
]}

机构：

[1] Fed Univ Para, Pharmaceut Sci Postgrad Program, Neurosci & Cellular Biol Postgrad Program, Fac Pharm, Ave Augusto Correa SN, BR-66075110 Guama, Para, Brazil

[2] Fed Univ Para UFPA, Hlth Sci Inst, Sch Pharm, Ave Augusto Correa SN, BR-66075110 Guama, Para, Brazil

来源：

NUTRIENTS | 2017年 / 9卷 / 12期

关键词：

autoimmunity; resveratrol; inflammation; organ-specific; systemic; FIBROBLAST-LIKE SYNOVIOCYTES; AMYOTROPHIC-LATERAL-SCLEROSIS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; TRANS-RESVERATROL; OXIDATIVE DAMAGE; PATHOGENESIS; MECHANISMS; APOPTOSIS; BIOAVAILABILITY;

D O I：

10.3390/nu9121306

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Autoimmune diseases are still considered to be pressing concerns due the fact that they are leaders in death and disability causes worldwide. Resveratrol is a polyphenol derived from a variety of foods and beverages, including red grapes and red wine. Anti-inflammatory, antioxidant, and antiaging properties of resveratrol have been reported, and in some animal and human studies this compound reduced and ameliorated the progression of autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, psoriasis, inflammatory bowel disease, and type 1 diabetes mellitus. Thus, this review aims to summarize and critically analyze the role of resveratrol in the modulation of several organ-specific or systemic autoimmune diseases.

引用

页数：22

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