Pathophysiology of age-related bone loss and osteoporosis

被引：245

作者：

Khosla, S ^{[1
]}

Riggs, BL ^{[1
]}

机构：

[1] Mayo Clin Coll Med, Div Metab Endocrinol & Nutr, Rochester, MN 55905 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2005年 / 34卷 / 04期

关键词：

D O I：

10.1016/j.ecl.2005.07.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

With the aging of the population, osteoporosis is an enormous and growing public health problem. Considerable work over the past decade has identified the role of age-related changes in sex steroid production or availability as playing a key role in mediating age-related bone loss in both sexes. Increasing serum parathyroid hormone levels with age also contribute to the late phase of bone loss in women and likely also in men. Superimposed on these fundamental mechanisms are a host of other factors, some present only in subsets of individuals, which contribute to increased bone loss and fracture risk.

引用

页码：1015 / +

页数：17

共 72 条

[21] Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human [J].

Giustina, A ;

Veldhuis, JD .

ENDOCRINE REVIEWS, 1998, 19 (06) :717-797

[22] Estrogen prevents glucocorticoid-induced apoptosis in osteoblasts in vivo and in vitro [J].

Gohel, A ;

McCarthy, MB ;

Gronowicz, G .

ENDOCRINOLOGY, 1999, 140 (11) :5339-5347

[23] Endogenous sex steroids and bone mineral density in older women and men: The Rancho Bernardo study [J].

Greendale, GA ;

Edelstein, S ;

BarrettConnor, E .

JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (11) :1833-1843

[24]

HEANEY RP, 1978, J LAB CLIN MED, V92, P953

[25] EFFECTS OF SEX AND AGE ON THE 24-HOUR PROFILE OF GROWTH-HORMONE SECRETION IN MAN - IMPORTANCE OF ENDOGENOUS ESTRADIOL CONCENTRATIONS [J].

HO, KY ;

EVANS, WS ;

BLIZZARD, RM ;

VELDHUIS, JD ;

MERRIAM, GR ;

SAMOJLIK, E ;

FURLANETTO, R ;

ROGOL, AD ;

KAISER, DL ;

THORNER, MO .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 64 (01) :51-58

[26] Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells [J].

Hofbauer, LC ;

Khosla, S ;

Dunstan, CR ;

Lacey, DL ;

Spelsberg, TC ;

Riggs, BL .

ENDOCRINOLOGY, 1999, 140 (09) :4367-4370

[27] ANDROSTENEDIONE AND TESTOSTERONE IN OVARIAN VENOUS AND PERIPHERAL PLASMA DURING OVARIECTOMY FOR BREAST CANCER [J].

HORTON, R ;

ROMANOFF, E ;

WALKER, J .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1966, 26 (11) :1267-+

[28] Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand [J].

Hsu, HL ;

Lacey, DL ;

Dunstan, CR ;

Solovyev, I ;

Colombero, A ;

Timms, E ;

Tan, HL ;

Elliott, G ;

Kelley, MJ ;

Sarosi, I ;

Wang, L ;

Xia, XZ ;

Elliott, R ;

Chiu, L ;

Black, T ;

Scully, S ;

Capparelli, C ;

Morony, S ;

Shimamoto, G ;

Bass, MB ;

Boyle, WJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) :3540-3545

[29] Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta [J].

Hughes, DE ;

Dai, AH ;

Tiffee, JC ;

Li, HH ;

Mundy, GR ;

Boyce, BF .

NATURE MEDICINE, 1996, 2 (10) :1132-1136

[30] INCREASED OSTEOCLAST DEVELOPMENT AFTER ESTROGEN LOSS - MEDIATION BY INTERLEUKIN-6 [J].

JILKA, RL ;

HANGOC, G ;

GIRASOLE, G ;

PASSERI, G ;

WILLIAMS, DC ;

ABRAMS, JS ;

BOYCE, B ;

BROXMEYER, H ;

MANOLAGAS, SC .

SCIENCE, 1992, 257 (5066) :88-91

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