Rat Mcs1b Is Concordant to the Genome-Wide Association-Identified Breast Cancer Risk Locus at Human 5q11.2 and MIER3 is a Candidate Cancer Susceptibility Gene

被引：19

作者：

denDekker, Aaron D.

Xu, Xin

Vaughn, M. Derek

Puckett, Aaron H.

Gardner, Louis L.

Lambring, Courtney J.

Deschenes, Lucas

Samuelson, David J. ^{[1
,2
]}

机构：

[1] Univ Louisville, Ctr Genet & Mol Med, Dept Biochem & Mol Biol, Hlth Sci Ctr, Louisville, KY 40292 USA

[2] Univ Louisville, James Graham Brown Canc Ctr, Louisville, KY 40292 USA

来源：

CANCER RESEARCH | 2012年 / 72卷 / 22期

关键词：

QUANTITATIVE TRAIT LOCUS; MAMMARY-CANCER; CONFER SUSCEPTIBILITY; MUTATION CARRIERS; NUCLEAR RECEPTOR; COMMON VARIANTS; ALLELES; CARCINOGENESIS; CONSORTIUM; PROTEIN;

D O I：

10.1158/0008-5472.CAN-12-0748

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Low-penetrance alleles associated with breast cancer risk have been identified in population-based studies. Most risk loci contain either no or multiple potential candidate genes. Rat mammary carcinoma susceptibility 1b (Mcs1b) is a quantitative trait locus on RN02 that confers decreased susceptibility when Copenhagen (COP)resistant alleles are introgressed into a Wistar Furth (WF)-susceptible genome. Five WF. COP congenic lines containing COP RN02 segments were compared. One line developed an average of 3.4 +/- 2.0 and 5.5 +/- 3.6 mammary carcinomas per rat +/- SD when females were Mcs1b-resistant homozygous and Mcs1b heterozygous, respectively. These phenotypes were significantly different from susceptible genotype littermates (7.8 +/- 3.1 mean mammary carcinomas per rat +/- SD, P = 0.0001 and P = 0.0413, respectively). All other congenic lines tested were susceptible. Thus, Mcs1b was narrowed to 1.8 Mb of RN02 between genetic markers ENSRNOSNP2740854 and g2UL2-27. Mammary gland-graft carcinoma susceptibility assays were used to determine that donor (P = 0.0019), but not recipient Mcs1b genotype (P = 0.9381), was associated with ectopic mammary carcinoma outcome. Rat Mcs1b contains sequence orthologous to human 5q11.2, a breast cancer susceptibility locus identified in multiple genome-wide association studies. Human/rat MAP3K1/Map3k1 and mesoderm induction early response (MIER; MIER3)/MIER3 are within these orthologous segments. We identified MIER3 as a candidate Mcs1b gene based on 4.5-fold higher mammary gland levels of MIER3 transcripts in susceptible compared with Mcs1b-resistant females. These data suggest that the human 5q11.2 breast cancer risk allele marked by rs889312 is mammary gland autonomous, and MIER3 is a candidate breast cancer susceptibility gene. Cancer Res; 72(22); 6002-12. (C) 2012 AACR.

引用

页码：6002 / 6012

页数：11

共 55 条

[1] Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2 [J].

Ahmed, Shahana ;

Thomas, Gilles ;

Ghoussaini, Maya ;

Healey, Catherine S. ;

Humphreys, Manjeet K. ;

Platte, Radka ;

Morrison, Jonathan ;

Maranian, Melanie ;

Pooley, Karen A. ;

Luben, Robert ;

Eccles, Diana ;

Evans, D. Gareth ;

Fletcher, Olivia ;

Johnson, Nichola ;

Silva, Isabel dos Santos ;

Peto, Julian ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Jacobs, Kevin ;

Prentice, Ross ;

Anderson, Garnet L. ;

Rajkovic, Aleksandar ;

Curb, J. David ;

Ziegler, Regina G. ;

Berg, Christine D. ;

Buys, Saundra S. ;

McCarty, Catherine A. ;

Feigelson, Heather Spencer ;

Calle, Eugenia E. ;

Thun, Michael J. ;

Diver, W. Ryan ;

Bojesen, Stig ;

Nordestgaard, Borge G. ;

Flyger, Henrik ;

Doerk, Thilo ;

Schuermann, Peter ;

Hillemanns, Peter ;

Karstens, Johann H. ;

Bogdanova, Natalia V. ;

Antonenkova, Natalia N. ;

Zalutsky, Iosif V. ;

Bermisheva, Marina ;

Fedorova, Sardana ;

Khusnutdinova, Elza ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong Young ;

Ahn, Sei-Hyun ;

Devilee, Peter ;

van Asperen, Christi J. .

NATURE GENETICS, 2009, 41 (05) :585-590

[2] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[3] Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers [J].

Antoniou, Antonis C. ;

Spurdle, Amanda B. ;

Sinilnikova, Olga M. ;

Healey, Sue ;

Pooley, Karen A. ;

Schmutzler, Rita K. ;

Versmold, Beatrix ;

Engel, Christoph ;

Meindl, Alfons ;

Arnold, Norbert ;

Hofmann, Wera ;

Sutter, Christian ;

Niederacher, Dieter ;

Deissler, Helmut ;

Caldes, Trinidad ;

Kampjarvi, Kati ;

Nevanlinna, Heli ;

Simard, Jacques ;

Beesley, Jonathan ;

Chen, Xiaoqing ;

Neuhausen, Susan L. ;

Rebbeck, Timothy R. ;

Wagner, Theresa ;

Lynch, Henry T. ;

Isaacs, Claudine ;

Weitzel, Jeffrey ;

Ganz, Patricia A. ;

Daly, Mary B. ;

Tomlinson, Gail ;

Olopade, Olufunmilayo I. ;

Bium, Joanne L. ;

Couch, Fergus J. ;

Peterlongo, Paolo ;

Manoukian, Siranoush ;

Barile, Monica ;

Radice, Paolo ;

Szabo, Csilla I. ;

Pereira, Lutecia H. Mateus ;

Greene, Mark H. ;

Rennert, Gad ;

Leibkowicz, Flavio ;

Barnett-Griness, Ofra ;

Andrulis, Irene L. ;

Ozcelik, Hilmi ;

Gerdes, Anne-Marie ;

Caligo, Maria A. ;

Laitman, Yael ;

Kaufman, Bella ;

Milgrom, Roni ;

Friedman, Eitan .

AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (04) :937-948

[4] A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population [J].

Antoniou, Antonis C. ;

Wang, Xianshu ;

Fredericksen, Zachary S. ;

McGuffog, Lesley ;

Tarrell, Robert ;

Sinilnikova, Olga M. ;

Healey, Sue ;

Morrison, Jonathan ;

Kartsonaki, Christiana ;

Lesnick, Timothy ;

Ghoussaini, Maya ;

Barrowdale, Daniel ;

Peock, Susan ;

Cook, Margaret ;

Oliver, Clare ;

Frost, Debra ;

Eccles, Diana ;

Evans, D. Gareth ;

Eeles, Ros ;

Izatt, Louise ;

Chu, Carol ;

Douglas, Fiona ;

Paterson, Joan ;

Stoppa-Lyonnet, Dominique ;

Houdayer, Claude ;

Mazoyer, Sylvie ;

Giraud, Sophie ;

Lasset, Christine ;

Remenieras, Audrey ;

Caron, Olivier ;

Hardouin, Agnes ;

Berthet, Pascaline ;

Hogervorst, Frans B. L. ;

Rookus, Matti A. ;

Jager, Agnes ;

van den Ouweland, Ans ;

Hoogerbrugge, Nicoline ;

van der Luijt, Rob B. ;

Meijers-Heijboer, Hanne ;

Garcia, Encarna B. Gomez ;

Devilee, Peter ;

Vreeswijk, Maaike P. G. ;

Lubinski, Jan ;

Jakubowska, Anna ;

Gronwald, Jacek ;

Huzarski, Tomasz ;

Byrski, Tomasz ;

Gorski, Bohdan ;

Cybulski, Cezary ;

Spurdle, Amanda B. .

NATURE GENETICS, 2010, 42 (10) :885-+

[5] Rats: gnawing through the barriers to understanding genetic susceptibility and breast cancer [J].

Blackburn, Anneke C. .

BREAST CANCER RESEARCH, 2011, 13 (05)

[6] Map Making in the 21st Century: Charting Breast Cancer Susceptibility Pathways in Rodent Models [J].

Blackburn, Anneke C. ;

Jerry, D. Joseph .

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2011, 16 (01) :57-64

[7] The transcriptional cofactor MIER1-beta negatively regulates histone acetyltransferase activity of the CREB-binding protein [J].

Blackmore T.M. ;

Mercer C.F. ;

Paterno G.D. ;

Gillespie L.L. .

BMC Research Notes, 1 (1)

[8] Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium [J].

Broeks, Annegien ;

Schmidt, Marjanka K. ;

Sherman, Mark E. ;

Couch, Fergus J. ;

Hopper, John L. ;

Dite, Gillian S. ;

Apicella, Carmel ;

Smith, Letitia D. ;

Hammet, Fleur ;

Southey, Melissa C. ;

Van 't Veer, Laura J. ;

de Groot, Renate ;

Smit, Vincent T. H. B. M. ;

Fasching, Peter A. ;

Beckmann, Matthias W. ;

Jud, Sebastian ;

Ekici, Arif B. ;

Hartmann, Arndt ;

Hein, Alexander ;

Schulz-Wendtland, Ruediger ;

Burwinkel, Barbara ;

Marme, Frederik ;

Schneeweiss, Andreas ;

Sinn, Hans-Peter ;

Sohn, Christof ;

Tchatchou, Sandrine ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Flyger, Henrik ;

Orsted, David D. ;

Kaur-Knudsen, Diljit ;

Milne, Roger L. ;

Perez, Jose I. Arias ;

Zamora, Pilar ;

Menendez Rodriguez, Primitiva ;

Benitez, Javier ;

Brauch, Hiltrud ;

Justenhoven, Christina ;

Ko, Yon-Dschun ;

Hamann, Ute ;

Fischer, Hans-Peter ;

Bruening, Thomas ;

Pesch, Beate ;

Chang-Claude, Jenny ;

Wang-Gohrke, Shan ;

Bremer, Michael ;

Karstens, Johann H. ;

Hillemanns, Peter ;

Doerk, Thilo ;

Nevanlinna, Heli A. .

HUMAN MOLECULAR GENETICS, 2011, 20 (16) :3289-3303

[9] Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium [J].

Cai, Qiuyin ;

Long, Jirong ;

Lu, Wei ;

Qu, Shimian ;

Wen, Wanqing ;

Kang, Daehee ;

Lee, Ji-Young ;

Chen, Kexin ;

Shen, Hongbing ;

Shen, Chen-Yang ;

Sung, Hyuna ;

Matsuo, Keitaro ;

Haiman, Christopher A. ;

Khoo, Ui Soon ;

Ren, Zefang ;

Iwasaki, Motoki ;

Gu, Kai ;

Xiang, Yong-Bing ;

Choi, Ji-Yeob ;

Park, Sue K. ;

Zhang, Lina ;

Hu, Zhibin ;

Wu, Pei-Ei ;

Noh, Dong-Young ;

Tajima, Kazuo ;

Henderson, Brian E. ;

Chan, Kelvin Y. K. ;

Su, Fengxi ;

Kasuga, Yoshio ;

Wang, Wenjing ;

Cheng, Jia-Rong ;

Yoo, Keun-Young ;

Lee, Jong-Young ;

Zheng, Hong ;

Liu, Yao ;

Shieh, Ya-Lan ;

Kim, Sung-Won ;

Lee, Jong Won ;

Iwata, Hiroji ;

Le Marchand, Loic ;

Chan, Sum Yin ;

Xie, Xiaoming ;

Tsugane, Shoichiro ;

Lee, Min Hyuk ;

Wang, Shenming ;

Li, Guoliang ;

Levy, Shawn ;

Huang, Bo ;

Shi, Jiajun ;

Delahanty, Ryan .

HUMAN MOLECULAR GENETICS, 2011, 20 (24) :4991-4999

[10] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium [J].

Campa, Daniele ;

Kaaks, Rudolf ;

Le Marchand, Loic ;

Haiman, Christopher A. ;

Travis, Ruth C. ;

Berg, Christine D. ;

Buring, Julie E. ;

Chanock, Stephen J. ;

Diver, W. Ryan ;

Dostal, Lucie ;

Fournier, Agnes ;

Hankinson, Susan E. ;

Henderson, Brian E. ;

Hoover, Robert N. ;

Isaacs, Claudine ;

Johansson, Mattias ;

Kolonel, Laurence N. ;

Kraft, Peter ;

Lee, I-Min ;

McCarty, Catherine A. ;

Overvad, Kim ;

Panico, Salvatore ;

Peeters, Petra H. M. ;

Riboli, Elio ;

Jose Sanchez, Maria ;

Schumacher, Fredrick R. ;

Skeie, Guri ;

Stram, Daniel O. ;

Thun, Michael J. ;

Trichopoulos, Dimitrios ;

Zhang, Shumin ;

Ziegler, Regina G. ;

Hunter, David J. ;

Lindstroem, Sara ;

Canzian, Federico .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2011, 103 (16) :1252-1263

← 1 2 3 4 5 6 →

共 55 条

[1] Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2 [J].

Ahmed, Shahana ;

Thomas, Gilles ;

Ghoussaini, Maya ;

Healey, Catherine S. ;

Humphreys, Manjeet K. ;

Platte, Radka ;

Morrison, Jonathan ;

Maranian, Melanie ;

Pooley, Karen A. ;

Luben, Robert ;

Eccles, Diana ;

Evans, D. Gareth ;

Fletcher, Olivia ;

Johnson, Nichola ;

Silva, Isabel dos Santos ;

Peto, Julian ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Jacobs, Kevin ;

Prentice, Ross ;

Anderson, Garnet L. ;

Rajkovic, Aleksandar ;

Curb, J. David ;

Ziegler, Regina G. ;

Berg, Christine D. ;

Buys, Saundra S. ;

McCarty, Catherine A. ;

Feigelson, Heather Spencer ;

Calle, Eugenia E. ;

Thun, Michael J. ;

Diver, W. Ryan ;

Bojesen, Stig ;

Nordestgaard, Borge G. ;

Flyger, Henrik ;

Doerk, Thilo ;

Schuermann, Peter ;

Hillemanns, Peter ;

Karstens, Johann H. ;

Bogdanova, Natalia V. ;

Antonenkova, Natalia N. ;

Zalutsky, Iosif V. ;

Bermisheva, Marina ;

Fedorova, Sardana ;

Khusnutdinova, Elza ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong Young ;

Ahn, Sei-Hyun ;

Devilee, Peter ;

van Asperen, Christi J. .

NATURE GENETICS, 2009, 41 (05) :585-590

[2] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[3] Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers [J].

Antoniou, Antonis C. ;

Spurdle, Amanda B. ;

Sinilnikova, Olga M. ;

Healey, Sue ;

Pooley, Karen A. ;

Schmutzler, Rita K. ;

Versmold, Beatrix ;

Engel, Christoph ;

Meindl, Alfons ;

Arnold, Norbert ;

Hofmann, Wera ;

Sutter, Christian ;

Niederacher, Dieter ;

Deissler, Helmut ;

Caldes, Trinidad ;

Kampjarvi, Kati ;

Nevanlinna, Heli ;

Simard, Jacques ;

Beesley, Jonathan ;

Chen, Xiaoqing ;

Neuhausen, Susan L. ;

Rebbeck, Timothy R. ;

Wagner, Theresa ;

Lynch, Henry T. ;

Isaacs, Claudine ;

Weitzel, Jeffrey ;

Ganz, Patricia A. ;

Daly, Mary B. ;

Tomlinson, Gail ;

Olopade, Olufunmilayo I. ;

Bium, Joanne L. ;

Couch, Fergus J. ;

Peterlongo, Paolo ;

Manoukian, Siranoush ;

Barile, Monica ;

Radice, Paolo ;

Szabo, Csilla I. ;

Pereira, Lutecia H. Mateus ;

Greene, Mark H. ;

Rennert, Gad ;

Leibkowicz, Flavio ;

Barnett-Griness, Ofra ;

Andrulis, Irene L. ;

Ozcelik, Hilmi ;

Gerdes, Anne-Marie ;

Caligo, Maria A. ;

Laitman, Yael ;

Kaufman, Bella ;

Milgrom, Roni ;

Friedman, Eitan .

AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (04) :937-948

[4] A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population [J].

Antoniou, Antonis C. ;

Wang, Xianshu ;

Fredericksen, Zachary S. ;

McGuffog, Lesley ;

Tarrell, Robert ;

Sinilnikova, Olga M. ;

Healey, Sue ;

Morrison, Jonathan ;

Kartsonaki, Christiana ;

Lesnick, Timothy ;

Ghoussaini, Maya ;

Barrowdale, Daniel ;

Peock, Susan ;

Cook, Margaret ;

Oliver, Clare ;

Frost, Debra ;

Eccles, Diana ;

Evans, D. Gareth ;

Eeles, Ros ;

Izatt, Louise ;

Chu, Carol ;

Douglas, Fiona ;

Paterson, Joan ;

Stoppa-Lyonnet, Dominique ;

Houdayer, Claude ;

Mazoyer, Sylvie ;

Giraud, Sophie ;

Lasset, Christine ;

Remenieras, Audrey ;

Caron, Olivier ;

Hardouin, Agnes ;

Berthet, Pascaline ;

Hogervorst, Frans B. L. ;

Rookus, Matti A. ;

Jager, Agnes ;

van den Ouweland, Ans ;

Hoogerbrugge, Nicoline ;

van der Luijt, Rob B. ;

Meijers-Heijboer, Hanne ;

Garcia, Encarna B. Gomez ;

Devilee, Peter ;

Vreeswijk, Maaike P. G. ;

Lubinski, Jan ;

Jakubowska, Anna ;

Gronwald, Jacek ;

Huzarski, Tomasz ;

Byrski, Tomasz ;

Gorski, Bohdan ;

Cybulski, Cezary ;

Spurdle, Amanda B. .

NATURE GENETICS, 2010, 42 (10) :885-+

[5] Rats: gnawing through the barriers to understanding genetic susceptibility and breast cancer [J].

Blackburn, Anneke C. .

BREAST CANCER RESEARCH, 2011, 13 (05)

[6] Map Making in the 21st Century: Charting Breast Cancer Susceptibility Pathways in Rodent Models [J].

Blackburn, Anneke C. ;

Jerry, D. Joseph .

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2011, 16 (01) :57-64

[7] The transcriptional cofactor MIER1-beta negatively regulates histone acetyltransferase activity of the CREB-binding protein [J].

Blackmore T.M. ;

Mercer C.F. ;

Paterno G.D. ;

Gillespie L.L. .

BMC Research Notes, 1 (1)

[8] Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium [J].

Broeks, Annegien ;

Schmidt, Marjanka K. ;

Sherman, Mark E. ;

Couch, Fergus J. ;

Hopper, John L. ;

Dite, Gillian S. ;

Apicella, Carmel ;

Smith, Letitia D. ;

Hammet, Fleur ;

Southey, Melissa C. ;

Van 't Veer, Laura J. ;

de Groot, Renate ;

Smit, Vincent T. H. B. M. ;

Fasching, Peter A. ;

Beckmann, Matthias W. ;

Jud, Sebastian ;

Ekici, Arif B. ;

Hartmann, Arndt ;

Hein, Alexander ;

Schulz-Wendtland, Ruediger ;

Burwinkel, Barbara ;

Marme, Frederik ;

Schneeweiss, Andreas ;

Sinn, Hans-Peter ;

Sohn, Christof ;

Tchatchou, Sandrine ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Flyger, Henrik ;

Orsted, David D. ;

Kaur-Knudsen, Diljit ;

Milne, Roger L. ;

Perez, Jose I. Arias ;

Zamora, Pilar ;

Menendez Rodriguez, Primitiva ;

Benitez, Javier ;

Brauch, Hiltrud ;

Justenhoven, Christina ;

Ko, Yon-Dschun ;

Hamann, Ute ;

Fischer, Hans-Peter ;

Bruening, Thomas ;

Pesch, Beate ;

Chang-Claude, Jenny ;

Wang-Gohrke, Shan ;

Bremer, Michael ;

Karstens, Johann H. ;

Hillemanns, Peter ;

Doerk, Thilo ;

Nevanlinna, Heli A. .

HUMAN MOLECULAR GENETICS, 2011, 20 (16) :3289-3303

[9] Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium [J].

Cai, Qiuyin ;

Long, Jirong ;

Lu, Wei ;

Qu, Shimian ;

Wen, Wanqing ;

Kang, Daehee ;

Lee, Ji-Young ;

Chen, Kexin ;

Shen, Hongbing ;

Shen, Chen-Yang ;

Sung, Hyuna ;

Matsuo, Keitaro ;

Haiman, Christopher A. ;

Khoo, Ui Soon ;

Ren, Zefang ;

Iwasaki, Motoki ;

Gu, Kai ;

Xiang, Yong-Bing ;

Choi, Ji-Yeob ;

Park, Sue K. ;

Zhang, Lina ;

Hu, Zhibin ;

Wu, Pei-Ei ;

Noh, Dong-Young ;

Tajima, Kazuo ;

Henderson, Brian E. ;

Chan, Kelvin Y. K. ;

Su, Fengxi ;

Kasuga, Yoshio ;

Wang, Wenjing ;

Cheng, Jia-Rong ;

Yoo, Keun-Young ;

Lee, Jong-Young ;

Zheng, Hong ;

Liu, Yao ;

Shieh, Ya-Lan ;

Kim, Sung-Won ;

Lee, Jong Won ;

Iwata, Hiroji ;

Le Marchand, Loic ;

Chan, Sum Yin ;

Xie, Xiaoming ;

Tsugane, Shoichiro ;

Lee, Min Hyuk ;

Wang, Shenming ;

Li, Guoliang ;

Levy, Shawn ;

Huang, Bo ;

Shi, Jiajun ;

Delahanty, Ryan .

HUMAN MOLECULAR GENETICS, 2011, 20 (24) :4991-4999

[10] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium [J].

Campa, Daniele ;

Kaaks, Rudolf ;

Le Marchand, Loic ;

Haiman, Christopher A. ;

Travis, Ruth C. ;

Berg, Christine D. ;

Buring, Julie E. ;

Chanock, Stephen J. ;

Diver, W. Ryan ;

Dostal, Lucie ;

Fournier, Agnes ;

Hankinson, Susan E. ;

Henderson, Brian E. ;

Hoover, Robert N. ;

Isaacs, Claudine ;

Johansson, Mattias ;

Kolonel, Laurence N. ;

Kraft, Peter ;

Lee, I-Min ;

McCarty, Catherine A. ;

Overvad, Kim ;

Panico, Salvatore ;

Peeters, Petra H. M. ;

Riboli, Elio ;

Jose Sanchez, Maria ;

Schumacher, Fredrick R. ;

Skeie, Guri ;

Stram, Daniel O. ;

Thun, Michael J. ;

Trichopoulos, Dimitrios ;

Zhang, Shumin ;

Ziegler, Regina G. ;

Hunter, David J. ;

Lindstroem, Sara ;

Canzian, Federico .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2011, 103 (16) :1252-1263

← 1 2 3 4 5 6 →