Synthesis of polyphenyls

被引：12

作者：

Chang, Meng-Yang ^{[1
]}

Lee, Tein-Wei ^{[1
]}

Lin, Shin-Ying ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 807, Taiwan

来源：

TETRAHEDRON | 2013年 / 69卷 / 01期

关键词：

Biphenyl-4,4 '-diol; Polyphenyls; Suzuki-Miyaura cross-coupling reaction; NBS-mediated bromination; Arylboronic acids; SUZUKI-MIYAURA REACTIONS; CROSS-COUPLING REACTIONS; TERPHENYL DERIVATIVES; EFFICIENT; OLIGORESORCINOLS; INHIBITORS; DESIGN;

D O I：

10.1016/j.tet.2012.10.039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile synthetic route toward functionalized 3-aryl-, 3,3'-diaryl-, 3,3',5-triaryl-4,4'-dimethoxybiphenyls (polyphenyls) 3-5 with the terphenyl, quaterphenyl, quinquephenyl, and sexiphenyl skeleton starting from biphenyl-4,4'-diol (1) in modest total yield is described. The route has been carried by the two transformations of the regioselective NBS (N-bromosuccinimide)-mediated bromination of 2 in MeCN at reflux and Suzuki-Miyaura cross-coupling reaction of the resulting bromides with arylboronic acids 6 in DME at reflux. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：228 / 234

页数：7

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