Total Synthesis of Seongsanamide B

被引：15

作者：

Shabani, Sadegh ^{[1
,2
]}

Hutton, Craig A. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia

[2] Univ Melbourne, Bio21 Mol Sci & Biotechnol Inst, Melbourne, Vic 3010, Australia

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 11期

基金：

澳大利亚研究理事会;

关键词：

INTRAMOLECULAR O-ARYLATION; ENANTIOSELECTIVE SYNTHESIS; ISODITYROSINE; PEPTIDES; K-13; (S; S)-ISODITYROSINE; MACROLACTAMIZATION; MACROCYCLIZATION; DITYROSINE; OF4949-III;

D O I：

10.1021/acs.orglett.0c01642

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of the bicyclic depsipeptide natural product seongsanamide B is described. The successful approach employed solid-phase peptide synthesis of a core heptapeptide, incorporating on-resin esterification, followed by solutionphase macrolactamization and a late stage intramolecular Evans-Chan-Lam coupling to generate the biaryl ether of the isodityrosine unit.

引用

页码：4557 / 4561

页数：5

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