Riluzole in psychiatry: a systematic review of the literature

被引：70
作者：
Zarate, Carlos A., Jr. [1 ]
Manji, Husseini K. [1 ]
机构：
[1] NIMH, Lab Mol Pathophysiol & Expt Therapeut, Mood & Anxiety Disorders Res Program, Bethesda, MD 20892 USA
来源：
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2008年 / 4卷 / 09期
关键词：
antidepressant; anxiety disorder; bipolar disorder; depression; glutamate; mania; plasticity; psychiatry; riluzole; treatment;
D O I：
10.1517/17425255.4.9.1223
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: The glutamate system seems to be an important contributor to the pathophysiology of mood and anxiety disorders. Thus, glutamatergic modulators are reasonable candidate drugs to test in patients with mood and anxiety disorders. Riluzole, a neuroprotective agent with anticonvulsant properties approved for the treatment of amyotrophic lateral sclerosis (ALS) is one such agent. Objective: To assess the potential risks and benefits of riluzole treatment in psychiatric patients. Methods: A PubMed search was performed using the keywords 'riluzole', 'inhibitor of glutamate release' and 'glutamatergic modulator' to identify all clinical studies and case reports involving riluzole in psychiatric patients. Results/conclusion: Riluzole's side effect profile is favorable and preliminary results regarding riluzole for the treatment of severe mood, anxiety and impulsive disorders are encouraging.
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收藏
页码：1223 / 1234
页数：12
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