Human-sized magnetic particle imaging for brain applications

被引：246

作者：

Graeser, M. ^{[1
,2
]}

Thieben, F. ^{[1
,2
]}

Szwargulski, P. ^{[1
,2
]}

Werner, F. ^{[1
,2
]}

Gdaniec, N. ^{[1
,2
]}

Boberg, M. ^{[1
,2
]}

Griese, F. ^{[1
,2
]}

Moeddel, M. ^{[1
,2
]}

Ludewig, P. ^{[3
]}

van de Ven, D. ^{[4
]}

Weber, O. M. ^{[5
]}

Woywode, O. ^{[6
]}

Gleich, B. ^{[7
]}

Knopp, T. ^{[1
,2
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Sect Biomed Imaging, D-20251 Hamburg, Germany

[2] Hamburg Univ Technol, Inst Biomed Imaging, D-21073 Hamburg, Germany

[3] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, D-20251 Hamburg, Germany

[4] Sensing & Inspect Technol GmbH, D-50354 Huerth, Germany

[5] Philips GmbH Market DACH, D-22335 Hamburg, Germany

[6] Philips Med Syst DMC GmbH, Imaging Components, D-22335 Hamburg, Germany

[7] Philips GmbH Innovat Technol, Res Labs, D-22335 Hamburg, Germany

来源：

NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期

关键词：

CONTRAST AGENT; PERFUSION; STROKE; TRACERS; LIVER;

D O I：

10.1038/s41467-019-09704-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Determining the brain perfusion is an important task for diagnosis of vascular diseases such as occlusions and intracerebral haemorrhage. Even after successful diagnosis, there is a high risk of restenosis or rebleeding such that patients need intense attention in the days after treatment. Within this work, we present a diagnostic tomographic imager that allows access to brain perfusion quantitatively in short intervals. The device is based on the magnetic particle imaging technology and is designed for human scale. It is highly sensitive and allows the detection of an iron concentration of 263 pmol(Fe) ml(-1), which is one of the lowest iron concentrations imaged by MPI so far. The imager is self-shielded and can be used in unshielded environments such as intensive care units. In combination with the low technical requirements this opens up a variety of medical applications and would allow monitoring of stroke on intensive care units.

引用

页数：9

共 47 条

[1]

[Anonymous], 2016, ARXIV160206072

[2]

[Anonymous], J PHYS D, DOI DOI 10.1088/0022-3727/42/2/022001

[3] Tomographic magnetic particle imaging of cancer targeted nanoparticles [J].

Arami, Hamed ;

Teeman, Eric ;

Troksa, Alyssa ;

Bradshaw, Haydin ;

Saatchi, Katayoun ;

Tomitaka, Asahi ;

Gambhir, Sanjiv Sam ;

Hafeli, Urs O. ;

Liggitt, Denny ;

Krishnan, Kannan M. .

NANOSCALE, 2017, 9 (47) :18723-18730

[4] MR perfusion and diffusion in acute ischemic stroke: human gray and white matter have different thresholds for infarction [J].

Bristow, MS ;

Simon, JE ;

Brown, RA ;

Eliasziw, M ;

Hill, MD ;

Coutts, SB ;

Frayne, R ;

Demchuk, AM ;

Mitchell, JR .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2005, 25 (10) :1280-1287

[5] Quantitative "Hot-Spot" Imaging of Transplanted Stem Cells Using Superparamagnetic Tracers and Magnetic Particle Imaging [J].

Bulte, Jeff W. M. ;

Walczak, Piotr ;

Janowski, Miroslaw ;

Krishnan, Kannan M. ;

Arami, Hamed ;

Halkola, Aleksi ;

Gleich, Bernhard ;

Rahmer, Juergen .

TOMOGRAPHY, 2015, 1 (02) :91-97

[6] High-resolution cerebral blood volume imaging in humans using the blood pool contrast agent ferumoxytol [J].

Christen, Thomas ;

Ni, Wendy ;

Qiu, Deqiang ;

Schmiedeskamp, Heiko ;

Bammer, Roland ;

Moseley, Michael ;

Zaharchuk, Greg .

MAGNETIC RESONANCE IN MEDICINE, 2013, 70 (03) :705-710

[7] Rodent Cerebral Blood Volume (CBV) changes during hypercapnia observed using Magnetic Particle Imaging (MPI) detection [J].

Cooley, Clarissa Zimmerman ;

Mandeville, Joseph B. ;

Mason, Erica E. ;

Mandeville, Emiri T. ;

Wald, Lawrence L. .

NEUROIMAGE, 2018, 178 :713-720

[8] Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010 [J].

Feigin, Valery L. ;

Forouzanfar, Mohammad H. ;

Krishnamurthi, Rita ;

Mensah, George A. ;

Connor, Myles ;

Bennett, Derrick A. ;

Moran, Andrew E. ;

Sacco, Ralph L. ;

Anderson, Laurie ;

Truelsen, Thomas ;

O'Donnell, Martin ;

Venketasubramanian, Narayanaswamy ;

Barker-Collo, Suzanne ;

Lawes, Carlene M. M. ;

Wang, Wenzhi ;

Shinohara, Yukito ;

Witt, Emma ;

Ezzati, Majid ;

Naghavi, Mohsen ;

Murray, Christopher .

LANCET, 2014, 383 (9913) :245-255

[9] Tomographic imaging using the nonlinear response of magnetic particles [J].

Gleich, B ;

Weizenecker, R .

NATURE, 2005, 435 (7046) :1214-1217

[10] Multidimensional X-Space Magnetic Particle Imaging [J].

Goodwill, Patrick W. ;

Conolly, Steven M. .

IEEE TRANSACTIONS ON MEDICAL IMAGING, 2011, 30 (09) :1581-1590

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