Comparisons of bone density and body composition among adolescents with anorexia nervosa and atypical anorexia nervosa

被引:29
作者
Nagata, Jason M. [1 ]
Carlson, Jennifer L. [2 ]
Golden, Neville H. [2 ]
Long, Jin [2 ]
Murray, Stuart B. [3 ]
Peebles, Rebecka [4 ]
机构
[1] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA
[2] Stanford Univ, Sch Med, Dept Pediat, Palo Alto, CA 94304 USA
[3] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
[4] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA
基金
美国国家卫生研究院;
关键词
anorexia nervosa; atypical anorexia nervosa; body composition; bone density; bone health; dual-energy x-ray absorptiometry; DXA; eating disorders; obesity; overweight; MINERAL DENSITY; SEX-DIFFERENCES; EATING-DISORDERS; REFERENCE CURVES; FRACTURE RISK; OSTEOPOROSIS; OVERWEIGHT; CHILDREN;
D O I
10.1002/eat.23048
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Objective To compare bone mineral density (BMD) and body composition among adolescents: (a) with atypical anorexia nervosa (AAN) versus anorexia nervosa (AN) and (b) those with and without a prior history of overweight. Method Electronic medical records of patients 9-20 years with AN or AAN who underwent dual-energy x-ray absorptiometry scans were retrospectively reviewed and analyzed. Results A total of 286 adolescents with AN or AAN were included. In linear regression models, AAN was associated with greater Z-scores in whole body bone mineral content (BMC, B = 0.88, p < 0.001), lumbar spine BMD (B = 0.79, p = 0.002), femoral neck BMD (B = 0.670, p = 0.009); fat mass index (B = 1.33, p = 0.003), and lean body mass index (LBMI, B = 1.10, p < 0.001) compared to AN, adjusting for age, sex, and duration of illness. A prior overweight history was associated with greater Z-scores in whole body BMC; lumbar spine BMD, total hip BMD, femoral neck BMD, and LBMI. Discussion Adolescents with AAN had higher BMD Z-scores than adolescents with AN; adolescents with a prior overweight history had greater BMD Z-scores than adolescents without a prior overweight history. These findings may inform clinical guidelines for the medical management of AAN.
引用
收藏
页码:591 / 596
页数:6
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