RASSF8 downregulation promotes lymphangiogenesis and metastasis in esophageal squamous cell carcinoma

被引：25

作者：

Zhang, Lan ^{[1
,3
,4
]}

Wang, Jian-Hua ^{[5
]}

Liang, Rong-Xin ^{[5
]}

Huang, Shu-Ting ^{[1
,3
,4
]}

Xu, Jing ^{[3
,4
]}

Yuan, Lin-Jing ^{[1
,3
,4
]}

Huang, Long ^{[6
]}

Zhou, Yun ^{[1
,3
,4
]}

Yu, Xing-Juan ^{[3
,4
]}

Wu, Shao-Yun ^{[3
,4
]}

Luo, Rong-Zhen ^{[2
,4
]}

Yun, Jing-Ping ^{[1
,2
,3
]}

Jia, Wei-Hua ^{[3
,4
]}

Zheng, Min ^{[1
,3
,4
]}

机构：

[1] Dept Gynecol, Guangzhou, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Ctr Canc, Dept Pathol, Guangzhou 510275, Guangdong, Peoples R China

[3] State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China

[4] Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China

[5] Second Peoples Hosp Guangdong Prov, Cardiovasc Dept, Guangzhou, Guangdong, Peoples R China

[6] Nanchang Univ, Affiliated Hosp 2, Dept Oncol, Nanchang, Peoples R China

来源：

ONCOTARGET | 2015年 / 6卷 / 33期

基金：

中国国家自然科学基金;

关键词：

tumor metastasis; RASSF8; lymphangiogenesis; esophageal cancer; GROWTH-FACTOR-C; NF-KAPPA-B; LYMPH-NODE METASTASIS; ENDOTHELIAL-CELLS; BREAST-CANCER; EXPRESSION; ANGIOGENESIS; SURVIVAL; CHEMOTHERAPY; INFLAMMATION;

D O I：

10.18632/oncotarget.5923

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lymphatic vessels are the major routes of human esophageal squamous cell carcinoma (ESCC) metastasis. Tumor cells secrete pro-lymphangiogenic factors to induce new lymphatic vessels, promoting lymph node metastasis. In this study, we show that RAS association domain family 8 (RASSF8) expression in ESCC clinical samples was inversely correlated with lymph node metastasis and patients survival. Tumor cells with low RASSF8 expression had higher apparent migratory ability, and promoted and lymphangiogenesis both in vitro and in vivo. RASSF8 downregulation enhanced VEGF-C expression and caused subcellular redistribution of p65 in ESCC. Our results show that RASSF8 acts as a tumor suppressor in ESCC and is a potential therapeutic target for preventing lymph node metastasis.

引用

页码：34510 / 34524

页数：15

共 42 条

[1] Role of the ras-association domain family 1 tumor suppressor gene in human cancers [J].

Agathanggelou, A ;

Cooper, WN ;

Latif, F .

CANCER RESEARCH, 2005, 65 (09) :3497-3508

[2] Interaction of tumor cells and lymphatic vessels in cancer progression [J].

Alitalo, A. ;

Detmar, M. .

ONCOGENE, 2012, 31 (42) :4499-4508

[3] Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo [J].

Björndahl, M ;

Cao, RH ;

Nissen, LJ ;

Clasper, S ;

Johnson, LA ;

Xue, Y ;

Zhou, ZJ ;

Jackson, D ;

Hansen, AJ ;

Cao, YH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (43) :15593-15598

[4] PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis [J].

Cao, RH ;

Björndahl, MA ;

Religa, P ;

Clasper, S ;

Garvin, S ;

Galter, D ;

Meister, B ;

Ikomi, F ;

Tritsaris, K ;

Dissing, S ;

Ohhashi, T ;

Jackson, DG ;

Cao, YH .

CANCER CELL, 2004, 6 (04) :333-345

[5] Dose-dependent response of FGF-2 for lymphangiogenesis [J].

Chang, LK ;

Garcia-Cardeña, G ;

Farnebo, F ;

Fannon, M ;

Chen, EJ ;

Butterfield, C ;

Moses, MA ;

Mulligan, RC ;

Folkman, J ;

Kaipainen, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11658-11663

[6] Medical progress - Esophageal cancer [J].

Enzinger, PC ;

Mayer, RJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (23) :2241-2252

[7] Identification of RASSF8 as a candidate lung tumor suppressor gene [J].

Falvella, F. S. ;

Manenti, G. ;

Spinola, M. ;

Pignatiello, C. ;

Conti, B. ;

Pastorino, U. ;

Dragani, T. A. .

ONCOGENE, 2006, 25 (28) :3934-3938

[8] Influenza A virus-encoded NS1 virulence factor protein inhibits innate immune response by targeting IKK [J].

Gao, Shijuan ;

Song, Liping ;

Li, Jiandong ;

Zhang, Zhenzhu ;

Peng, Haiyan ;

Jiang, Wei ;

Wang, Qingtao ;

Kang, Tiebang ;

Chen, Shuai ;

Huang, Wenlin .

CELLULAR MICROBIOLOGY, 2012, 14 (12) :1849-1866

[9] Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix [J].

Gombos, Z ;

Xu, XW ;

Chu, CS ;

Zhang, PJ ;

Acs, G .

CLINICAL CANCER RESEARCH, 2005, 11 (23) :8364-8371

[10] Immunity, Inflammation, and Cancer [J].

Grivennikov, Sergei I. ;

Greten, Florian R. ;

Karin, Michael .

CELL, 2010, 140 (06) :883-899

← 1 2 3 4 5 →