Galactomannan, a Surrogate Marker for Outcome in Invasive Aspergillosis: Finally Coming of Age

被引：63
作者：
Mercier, Toine [1 ,2 ]
Guldentops, Ellen [2 ]
Lagrou, Katrien [1 ,3 ,4 ]
Maertens, Johan [1 ,2 ]
机构：
[1] Katholieke Univ Leuven, Lab Clin Bacteriol & Mycol, Dept Microbiol & Immunol, Leuven, Belgium
[2] Univ Hosp Leuven, Dept Hematol, Leuven, Belgium
[3] Univ Hosp Leuven, Dept Lab Med, Leuven, Belgium
[4] Univ Hosp Leuven, Natl Reference Ctr Mycosis, Leuven, Belgium
来源：
FRONTIERS IN MICROBIOLOGY | 2018年 / 9卷
关键词：
galactomannan; kinetics; invasive aspergillosis; prognosis; outcome; CELL TRANSPLANT RECIPIENTS; MYCOSES STUDY-GROUP; PULMONARY ASPERGILLOSIS; SERUM GALACTOMANNAN; NEUTROPENIC PATIENTS; ENZYME-IMMUNOASSAY; ANTIFUNGAL THERAPY; CIRCULATING GALACTOMANNAN; EUROPEAN-ORGANIZATION; CASPOFUNGIN THERAPY;
D O I：
10.3389/fmicb.2018.00661
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Detection of galactomannan has become widely available for diagnosing invasive aspergillosis. The test characteristics, using the Platelia (TM) enzyme-immunoassay, have been well described. This assay could potentially also be useful for the early evaluation of the efficacy of antifungal therapy and for predicting the outcome in terms of response and survival. In this systematic review, we assessed the available evidence for the use of serum galactomannan at baseline as a prognostic marker, and the predictive value of serum galactomannan kinetics after initiation of antifungal therapy. Overall, serum galactomannan at baseline and galactomannan kinetics appear to be good predictors of therapy response and survival. However, breakpoints for predicting therapy failure and validation in different patient populations are still lacking.
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页数：10
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