Cellular Level Biocompatibility and Biosafety of ZnO Nanowires

被引：283
作者：
Li, Zhou [1 ,2 ]
Yang, Rusen [1 ]
Yu, Min [3 ]
Bai, Fan [1 ]
Li, Cheng [1 ]
Wang, Zhong Lin [1 ]
机构：
[1] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA
[2] Peking Univ, Dept Adv Mat & Nanotechnol, Beijing 100871, Peoples R China
[3] Peking Univ, Dept Biomed Engn, Beijing 100871, Peoples R China
来源：
JOURNAL OF PHYSICAL CHEMISTRY C | 2008年 / 112卷 / 51期
关键词：
D O I：
10.1021/jp808878p
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We report the first cellular level study on the biocompatibility and biosafety of ZnO nanowires (NWs). Hela cell line showed a complete biocompatibility to ZnO nanostructures from low to high NW concentrations beyond a couple of production periods. The L929 cell line showed a good reproduction behavior at lower NW concentration, but when the concentration was close to 100 mu g/ml, the viability dropped to similar to 50%. Our study shows the biocompetability and biosafety of ZnO NWs when they are applied in biological applications at normal concentration range.
引用
收藏
页码：20114 / 20117
页数：4
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