Properties of mixed backbone oligonucleotides containing 3′-O-methyl ribonucleosides.

被引：3
|
作者：
Kumar, P
Takaku, H
机构：
[1] Chiba Inst Technol, High Technol Res Ctr, Chiba 2750016, Japan
[2] Chiba Inst Technol, Dept Ind Chem, Chiba 2750016, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 17期
关键词：
D O I：
10.1016/S0960-894X(99)00414-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Oligonucleotides containing 3'-O-methyl ribonucleosides were synthesized, and their thermal stabilities and global conformations with RNA and DNA have been studied. The duplexes displayed lower T-m values as compared to the unmodified ones, and adopted A-conformations. Furthermore, they are not a substrate for RNase H, are slightly resistant to snake venom phosphodiesterase, and are not cleaved by nuclease S1 (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2515 / 2520
页数：6
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