Plasma C-Type Natriuretic Peptide: Emerging Applications in Disorders of Skeletal Growth

被引:19
作者
Espiner, Eric [1 ]
Prickett, Tim [1 ]
Olney, Robert [2 ]
机构
[1] Univ Otago, Dept Med, 2 Riccarton Ave,POB 4345, Christchurch 8140, New Zealand
[2] Nemours Childrens Specialty Care, Div Endocrinol, Jacksonville, FL USA
来源
HORMONE RESEARCH IN PAEDIATRICS | 2018年 / 90卷 / 06期
关键词
NTproCNP; Height velocity; Endochondral bone growth; Growth hormone; Skeletal dysplasia; Biomarker; AMINO-TERMINAL PROPEPTIDE; OF-FUNCTION MUTATIONS; RECEPTOR-B NPR2; HETEROZYGOUS MUTATIONS; HUMAN CIRCULATION; LINEAR GROWTH; TALL STATURE; CNP; CHILDREN; FORMS;
D O I
10.1159/000496544
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although studies in experimental animals show that blood levels of C-type natriuretic peptide (CNP) and its bioinactive aminoterminal propeptide (NTproCNP) are potential biomarkers of long bone growth, a lack of suitable assays and appropriate reference ranges has limited the application of CNP measurements in clinical practice. Plasma concentrations of the processed product of proCNP, NTproCNP - and to a lesser extent CNP itself - correlate with concurrent height velocity throughout all phases of normal skeletal growth, as well as during interventions known to affect skeletal growth in children. Since a change in levels precedes a measurable change in height velocity during interventions, measuring NTproCNP may have predictive value in clinical practice. Findings from a variety of genetic disorders affecting CNP signaling suggest that plasma concentrations of both peptides may be helpful in diagnosis, provided factors such as concurrent height velocity, feedback regulation of CNP, and differential changes in peptide clearance are considered when interpreting values. An improved understanding of factors affecting plasma levels, and the availability of commercial kits enabling accurate measurement using small volumes of plasma, can be expected to facilitate potential applications in growth disorders including genetic causes (C) affecting the CNP signaling pathway. (c) 2019 S. Karger AG, Basel
引用
收藏
页码:345 / 357
页数:13
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