6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis

被引：53

作者：

Kempen, Isabelle ^{[1
]}

Hemmer, Marc ^{[1
]}

Counerotte, Stephane ^{[1
]}

Pochet, Lionel ^{[2
]}

de Tullio, Pascal ^{[1
]}

Foidart, Jean-Michel ^{[3
]}

Blacher, Silvia ^{[3
]}

Noel, Agnes ^{[3
]}

Frankenne, Francis ^{[3
]}

Pirotte, Bernard ^{[1
]}

机构：

[1] Univ Liege, Lab Chim Pharmaceut, Drug Res Ctr, B-4000 Liege, Belgium

[2] Univ Namur, Dept Pharm, FUNDP, B-5000 Namur, Belgium

[3] Univ Liege, Lab Biol Tumeurs & Dev, B-4000 Liege, Belgium

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 12期

关键词：

Coumarin derivatives; Cancer; Cell invasion; Anti-cancer drug;

D O I：

10.1016/j.ejmech.2008.01.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure-activity relationships were deduced from biological results and will be used in further design of new active compounds. In particular, the acetoxymethyl substituent found at the 6-position of previously described active compounds can be replaced by an acetamidomethyl substituent without loss of potency; while the presence of an aryl ester function at the 3-position was preferred to a thioester or an amide function to induce marked biological activity. This work confirms the interest of aryl esters of 6-substituted coumarin-3-carboxylic acids as potential new anti-cancer agents. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：2735 / 2750

页数：16

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