Superparamagnetic iron oxide based nanoprobes for imaging and theranostics

被引：82
作者：
Lam, Tina [1 ]
Pouliot, Philippe [2 ,3 ]
Avti, Pramod K. [1 ,2 ,3 ]
Lesage, Frederic [2 ,3 ]
Kakkar, Ashok K. [1 ]
机构：
[1] McGill Univ, Dept Chem, Montreal, PQ H3A 0B8, Canada
[2] Ecole Polytech, CP 6079 Succ Ctr Ville, Montreal, PQ H3C 3A7, Canada
[3] Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada
来源：
ADVANCES IN COLLOID AND INTERFACE SCIENCE | 2013年 / 199卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
Superparamagnetic iron oxide nanoparticles (SPIONs); Magnetic resonance imaging (MRI); Cardiovascular disease; Synthesis; Physicochemical properties; MRI CONTRAST AGENT; CONTINUOUS HYDROTHERMAL SYNTHESIS; SIZE-CONTROLLED SYNTHESIS; MESENCHYMAL STEM-CELLS; ONE-POT SYNTHESIS; MAGNETIC-RESONANCE; IN-VIVO; FE3O4; NANOPARTICLES; ATHEROSCLEROTIC PLAQUE; PARTICLE-SIZE;
D O I：
10.1016/j.cis.2013.06.007
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The need to target, deliver and subsequently evaluate the efficacy of therapeutics in the treatment of a disease has provided added impetus in developing novel and highly efficient contrast agents. Superparamagnetic iron oxide nanoparticles (SPIONs) have offered tremendous potential in designing advanced magnetic resonance imaging (MRI) diagnostic agents, due to their unique physicochemical properties. There has been tremendous effort devoted in the recent past in developing synthetic methodologies through which their size, hydrodynamic radii, chemical composition and morphologies could be tailored at the nanoscale. This enables one to fine tune their magnetic behavior, and thus their MRI response. While novel synthetic strategies are being assembled for directing SPIONs to the diseased site as well as imparting them stealth and biocompatibility, it is also essential to evaluate their biological toxicological profiles. This review highlights recent advances that have been made in the synthesis of SPIONs, subsequent functionalization with desired entities, and a discussion on their use as MRI contrast agents in cardiovascular research. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：95 / 113
页数：19
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