Vitamin E dependent microRNA regulation in rat liver

被引：87

作者：

Gaedicke, Sonja ^{[1
]}

Zhang, Xiangnan ^{[2
]}

Schmelzer, Constance ^{[1
]}

Lou, Yijia ^{[2
]}

Doering, Frank ^{[1
]}

Frank, Jan ^{[1
]}

Rimbach, Gerald ^{[1
]}

机构：

[1] Univ Kiel, Inst Human Nutr & Food Sci, D-24118 Kiel, Germany

[2] Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmacol & Toxicol, Hangzhou 310058, Zhejiang, Peoples R China

来源：

FEBS LETTERS | 2008年 / 582卷 / 23-24期

关键词：

MicroRNA; Vitamin E; Tocopherol; Post-transcriptional gene regulation; Rat; Liver;

D O I：

10.1016/j.febslet.2008.09.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dietary vitamin E (VE) is known to regulate gene expression by altering mRNA concentrations. Recently, microRNA (miRNA) have been discovered as a means of posttranscriptional gene regulation. Since the effect of VE on miRNA regulation is unknown, we fed rats for 6 months diets deficient or sufficient in VE and determined hepatic concentrations of miRNA involved in processes previously associated with VE (lipid metabolism, miRNA-122a; cancer and inflammation, miRNA-125b). VE-deficiency resulted in reduced concentrations of miRNA-122a and miRNA-125b. The findings of the present study demonstrate that differences in dietary VE may affect hepatic miRNA concentrations in vivo.

引用

页码：3542 / 3546

页数：5

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