Biomarkers of pathophysiology in hypertrophic cardiomyopathy: implications for clinical management and prognosis

被引：74
作者：
Cambronero, Francisco [2 ]
Marin, Francisco [2 ]
Roldan, Vanessa [3 ]
Hernandez-Romero, Diana [2 ]
Valdes, Mariano [2 ]
Lip, Gregory Y. H. [1 ]
机构：
[1] City Hosp, Univ Dept Med, Haemostasis Thrombosis & Vasc Biol Unit, Birmingham B18 7QH, W Midlands, England
[2] Hosp Univ Virgen Arrixaca, Dept Cardiol, Murcia, Spain
[3] Univ Murcia, Ctr Reg Hemodonac, E-30001 Murcia, Spain
来源：
EUROPEAN HEART JOURNAL | 2009年 / 30卷 / 02期
关键词：
TUMOR-NECROSIS-FACTOR; BRAIN NATRIURETIC PEPTIDE; ACUTE CORONARY SYNDROMES; CARDIAC TROPONIN-T; ALPHA-MHC403/+ MOUSE MODEL; VON-WILLEBRAND-FACTOR; GROWTH-FACTOR-I; FACTOR-ALPHA; HEART-FAILURE; OBSTRUCTIVE CARDIOMYOPATHY;
D O I：
10.1093/eurheartj/ehn538
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The study of biomarkers and their signalling pathways has allowed the development of new therapeutic strategies in a range of disorders. The aim of the present systematic review is to provide an overview of different biomarkers in patients with hypertrophic cardiomyopathy that could give some insight into the pathophysiologic mechanism(s) underlying the typical clinical and histological manifestations of the disease. Several pathophysiological models are presented and discussed, including studies that have investigated these biomarkers for diagnostic and prognostic reasons, in relation to disease progression and/or mortality.
引用
收藏
页码：139 / 151
页数：13
相关论文
共 135 条
[1]   PURIFICATION OF HUMAN VERY-LONG-CHAIN ACYL-COENZYME-A DEHYDROGENASE AND CHARACTERIZATION OF ITS DEFICIENCY IN 7 PATIENTS [J].
AOYAMA, T ;
SOURI, M ;
USHIKUBO, S ;
KAMIJO, T ;
YAMAGUCHI, S ;
KELLEY, RI ;
RHEAD, WJ ;
UETAKE, K ;
TANAKA, K ;
HASHIMOTO, T .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (06) :2465-2473
[2]   Effect of Losartan on left ventricular diastolic function in patients with nonobstructive hypertrophic cardiomyopathy [J].
Araujo, AQ ;
Arteaga, E ;
Ianni, BM ;
Buck, PC ;
Rabello, R ;
Mady, C .
AMERICAN JOURNAL OF CARDIOLOGY, 2005, 96 (11) :1563-1567
[3]   Inflammatory biomarkers in acute coronary syndromes Part IV: Matrix metalloproteinases and biomarkers of platelet activation [J].
Armstrong, EJ ;
Morrow, DA ;
Sabatine, MS .
CIRCULATION, 2006, 113 (09) :E382-E385
[4]   Inflammatory biomarkers in acute coronary syndromes - Part III: Biomarkers of oxidative stress and angiogenic growth factors [J].
Armstrong, EJ ;
Morrow, DA ;
Sabatine, MS .
CIRCULATION, 2006, 113 (08) :E289-E292
[5]   Inflammatory biomarkers in acute coronary syndromes - Part II: Acute-phase reactants and biomarkers of endothelial cell activation [J].
Armstrong, EJ ;
Morrow, DA ;
Sabatine, MS .
CIRCULATION, 2006, 113 (07) :E152-E155
[6]   Inflammatory biomarkers in acute coronary syndromes Part I: Introduction and cytokines [J].
Armstrong, EJ ;
Morrow, DA ;
Sabatine, MS .
CIRCULATION, 2006, 113 (06) :E72-E75
[7]   Plasma amino-terminal pro-B-type natriuretic peptide quantification in hypertrophic cardiomyopathy [J].
Arteaga, E ;
Araujo, AQ ;
Buck, P ;
Ianni, BM ;
Rabello, R ;
Mady, C .
AMERICAN HEART JOURNAL, 2005, 150 (06) :1228-1232
[8]   Hypertrophic cardiomyopathy: a paradigm for myocardial energy depletion [J].
Ashrafian, H ;
Redwood, C ;
Blair, E ;
Watkins, H .
TRENDS IN GENETICS, 2003, 19 (05) :263-268
[9]   HMG CoA reductase inhibition and left ventricular mass in hypertrophic cardiomyopathy:: a randomized placebo-controlled pilot study [J].
Bauersachs, J. ;
Stork, S. ;
Kung, M. ;
Waller, C. ;
Fidler, F. ;
Hoyer, C. ;
Frantz, S. ;
Weidemann, F. ;
Ertl, G. ;
Angermann, C. E. .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2007, 37 (11) :852-859
[10]   Mutations in the γ2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy:: evidence for the central role of energy compromise in disease pathogenesis [J].
Blair, E ;
Redwood, C ;
Ashrafian, H ;
Oliveira, M ;
Broxholme, J ;
Kerr, B ;
Salmon, A ;
Östman-Smith, I ;
Watkins, H .
HUMAN MOLECULAR GENETICS, 2001, 10 (11) :1215-1220
12345678910