A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections

被引：11

作者：

Blaskovich, Mark A. T. ^{[1
]}

Hansford, Karl A. ^{[1
]}

Butler, Mark S. ^{[1
]}

Ramu, Soumya ^{[1
]}

Kavanagh, Angela M. ^{[1
]}

Jarrad, Angie M. ^{[1
]}

Prasetyoputri, Anggia ^{[1
,21
]}

Pitt, Miranda E. ^{[1
,22
]}

Huang, Johnny X. ^{[1
,23
]}

Lindahl, Fredrik ^{[1
]}

Ziora, Zyta M. ^{[1
]}

Bradford, Tanya ^{[1
]}

Muldoon, Craig ^{[1
]}

Rajaratnam, Premraj ^{[1
,24
]}

Pelingon, Ruby ^{[1
]}

Edwards, David J. ^{[1
]}

Zhang, Bing ^{[1
]}

Amado, Maite ^{[1
]}

Elliott, Alysha G. ^{[1
]}

Zuegg, Johannes ^{[1
]}

Coin, Lachlan ^{[1
,22
]}

Woischnig, Anne-Kathrin ^{[2
,3
,4
]}

Khanna, Nina ^{[2
,3
,4
]}

Breidenstein, Elena ^{[5
]}

Stincone, Anna ^{[5
,25
]}

Mason, Clive ^{[5
]}

Khan, Nawaz ^{[5
]}

Cho, Hye-Kyung ^{[6
]}

Karau, Melissa J. ^{[6
]}

Greenwood-Quaintance, Kerryl E. ^{[6
]}

Patel, Robin ^{[6
,7
]}

Wootton, Mandy ^{[8
]}

James, Meagan L. ^{[9
,10
]}

Hutton, Melanie L. ^{[9
,10
]}

Lyras, Dena ^{[9
,10
]}

Ogunniyi, Abiodun D. ^{[11
]}

Mahdi, Layla K. ^{[11
,26
]}

Trott, Darren J. ^{[11
]}

Wu, Xiaoqian ^{[12
]}

Niles, Samantha ^{[12
]}

Lewis, Kim ^{[12
]}

Smith, Jordan R. ^{[13
,27
]}

Barber, Katie E. ^{[13
,28
]}

Yim, Juwon ^{[13
]}

Rice, Seth Alan ^{[13
]}

Rybak, Michael J. ^{[13
,14
]}

Ishmael, Chad R. ^{[15
]}

Hori, Kellyn R. ^{[15
]}

Bernthal, Nicholas M. ^{[15
]}

Francis, Kevin P. ^{[15
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Ctr Superbug Solut, St Lucia, Qld 4072, Australia

[2] Univ Basel, Hebelstr 20, CH-4031 Basel, Switzerland

[3] Univ Hosp Basel, Div Infect Dis, Dept Biomed, Hebelstr 20, CH-4031 Basel, Switzerland

[4] Univ Hosp Basel, Infect Biol Lab, Dept Biomed, Hebelstr 20, CH-4031 Basel, Switzerland

[5] Summit Therapeut, Works, Unity Campus, Pampisford CB22 3FT, Cambs, England

[6] Mayo Clin, Div Clin Microbiol, Dept Lab Med & Pathol, Rochester, MN USA

[7] Mayo Clin, Div Publ Hlth Infect Dis & Occupat Med, Dept Med, Rochester, MN 55905 USA

[8] Univ Hosp Wales, Specialist Antimicrobial Chemotherapy Unit Publ H, Heath Pk, Cardiff CF14 4XW, Wales

[9] Monash Univ, Monash Biomed Discovery Inst, Infect & Immun Program, Clayton, Vic 3800, Australia

[10] Monash Univ, Dept Microbiol, Clayton, Vic 3800, Australia

[11] Univ Adelaide, Sch Anim & Vet Sci, Australian Ctr Antimicrobial Resistance Ecol, Roseworthy, SA 5371, Australia

[12] Northeastern Univ, Dept Biol, Antimicrobial Discovery Ctr, 360 Huntington Ave, Boston, MA 02115 USA

[13] Wayne State Univ, Eugene Applebaum Coll Pharm & Hlth Sci, Antiinfect Res Lab, Detroit, MI 48201 USA

[14] Wayne State Univ, Sch Med, Detroit, MI 48201 USA

[15] Univ Calif Los Angeles UCLA, Dept Orthopaed Surg, Los Angeles, CA 90095 USA

[16] PerkinElmer, 68 Elm St, Hopkinton, MA 01748 USA

[17] Univ Queensland, Clin Res Ctr, Fac Med, Brisbane, Qld 4029, Australia

[18] Royal Brisbane & Womens Hosp, Dept Pharm, Brisbane, Qld 4029, Australia

[19] Royal Brisbane & Womens Hosp, Dept Intens Care Med, Brisbane, Qld 4029, Australia

[20] Univ Montpellier, Nimes Univ Hosp, Div Anaesthesiol Crit Care Emergency & Pain Med, F-30029 Nimes, France

[21] Res Ctr Appl Microbiol, Natl Res & Innovat Agcy, Bogor, West Java, Indonesia

[22] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic 3000, Australia

[23] Weifang Med Univ, Sch Life Sci & Technol, Weifang 261053, Shandong, Peoples R China

[24] Griffith Univ, Inst Glyc, Brisbane, Qld 4222, Australia

[25] Aptuit, Via Alessandro Fleming 4, I-37135 Verona, VR, Italy

[26] Univ South Australia, UniSA Clin & Hlth Sci, Adelaide, SA 5000, Australia

[27] High Point Univ, Coll Pharm, High Point, NC 27262 USA

[28] Univ Mississippi, Sch Pharm, University, MS 38677 USA

[29] Sitala Bio, D6 Grain House,Mill Court, Cambridge CB22 5LD, England

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2022年 / 14卷 / 662期

基金：

英国惠康基金; 澳大利亚国家健康与医学研究理事会;

关键词：

IN-VITRO ACTIVITY; VIVO MOUSE MODEL; STAPHYLOCOCCUS-AUREUS; STREPTOCOCCUS-PNEUMONIAE; BACTERIAL BURDEN; DAPTOMYCIN; EFFICACY; VANCOMYCIN; TELAVANCIN; THERAPY;

D O I：

10.1126/scitranslmed.abj2381

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Drug-resistant Gram-positive bacterial infections are still a substantial burden on the public health system, with two bacteria (Staphylococcus aureus and Streptococcus pneumoniae) accounting for over 1.5 million drug-resistant infections in the United States alone in 2017. In 2019, 250,000 deaths were attributed to these pathogens globally. We have developed a preclinical glycopeptide antibiotic, MCC5145, that has excellent potency (MIC90 <= 0.06 mu g/ml) against hundreds of isolates of methicillin-resistant S. aureus ( MRSA) and other Gram-positive bacteria, with a greater than 1000-fold margin over mammalian cell cytotoxicity values. The antibiotic has therapeutic in vivo efficacy when dosed subcutaneously in multiple murine models of established bacterial infections, including thigh infection with MRSA and blood septicemia with S. pneumoniae, as well as when dosed orally in an antibiotic-induced Clostridioides difficile infection model. MCC5145 exhibited reduced nephrotoxicity at microbiologically active doses in mice compared to vancomycin. MCC5145 also showed improved activity against biofilms compared to vancomycin, both in vitro and in vivo, and a low propensity to select for drug resistance. Characterization of drug action using a transposon library bioinformatic platform showed a mechanistic distinction from other glycopeptide antibiotics.

引用

页数：16

共 50 条

[41] Infections caused by Gram-positive bacteria: a review of the global challenge [J].

Woodford, Neil ;

Livermore, David M. .

JOURNAL OF INFECTION, 2009, 59 :S4-S16

[42] Daptomycin use in neutropenic patients with documented gram-positive infections [J].

Rolston, Kenneth V. I. ;

Besece, Dina ;

Lamp, Kenneth C. ;

Yoon, Min ;

McConnell, Scott A. ;

White, Pamela .

SUPPORTIVE CARE IN CANCER, 2014, 22 (01) :7-14

[43] Daptomycin therapy for invasive Gram-positive bacterial infections in children [J].

Ardura, Monica I. ;

Mejias, Asuncion ;

Katz, Kathy S. ;

Revell, Paula ;

McCracken, George H., Jr. ;

Sanchez, Pablo J. .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2007, 26 (12) :1128-1132

[44] Gram-positive pneumonia [J].

Olayemi Osiyemi ;

Gordon Dickinson .

Current Infectious Disease Reports, 2000, 2 (3) :207-214

[45] Antibiotic resistance among clinically important Gram-positive bacteria in the UK [J].

Johnson, AP .

JOURNAL OF HOSPITAL INFECTION, 1998, 40 (01) :17-26

[46] Daptomycin: an evidence-based review of its role in the treatment of Gram-positive infections [J].

Gonzalez-Ruiz, Armando ;

Seaton, R. Andrew ;

Hamed, Kamal .

INFECTION AND DRUG RESISTANCE, 2016, 9 :47-58

[47] Biofilm-related disease [J].

Luis Del Pozo, Jose .

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2018, 16 (01) :51-65

[48] Biofilm Forming Antibiotic Resistant Gram-Positive Pathogens Isolated From Surfaces on the International Space Station [J].

Sobisch, Lydia-Yasmin ;

Rogowski, Katja Marie ;

Fuchs, Jonathan ;

Schmieder, Wilhelm ;

Vaishampayan, Ankita ;

Oles, Patricia ;

Novikova, Natalia ;

Grohmann, Elisabeth .

FRONTIERS IN MICROBIOLOGY, 2019, 10

[49] Daptomycin - a novel antibiotic against Gram-positive pathogens [J].

LaPlante, KL ;

Rybak, MJ .

EXPERT OPINION ON PHARMACOTHERAPY, 2004, 5 (11) :2321-2331

[50] Porphyrin nanoemulsion for antimicrobial photodynamic therapy: effective delivery to inactivate biofilm-related infections [J].

Buzza, Hilde Harb ;

Alves, Fernanda ;

Tome, Ana Julia Barbosa ;

Chen, Juan ;

Kassab, Giulia ;

Bu, Jiachuan ;

Bagnato, Vanderlei Salvador ;

Zheng, Gang ;

Kurachi, Cristina .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (46)

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