Improved Anti-Tumor Response of Chimeric Antigen Receptor T Cell (CART) Therapy after GM-CSF Inhibition Is Mechanistically Supported By a Novel Direct Interaction of GM-CSF with Activated Carts

被引：6

作者：

Cox, Michelle J. ^{[1
,2
,3
]}

Kuhlmann, Charles J. ^{[3
]}

Sterner, Rosalie M. ^{[3
]}

Sakemura, Reona ^{[2
,3
]}

Sinha, Sutapa ^{[2
]}

Mwangi, Raphael ^{[1
,4
]}

Scott, Nancy ^{[1
,5
]}

Hefazi, Mehrdad ^{[2
,3
]}

Ahmed, Omar ^{[6
]}

Chappell, Dale ^{[6
]}

Durrant, Cameron ^{[6
]}

Roman, Claudia Manriquez ^{[2
,3
,7
]}

Schick, Kendall J. ^{[2
,3
,7
,8
]}

Tapper, Erin E. ^{[2
,3
]}

Horvei, Paulina ^{[3
,9
]}

Ruff, Michael W. ^{[3
,10
]}

Parikh, Sameer A. ^{[2
]}

Kay, Neil E. ^{[2
]}

Kenderian, Saad S. ^{[2
,3
,11
,12
]}

机构：

[1] Univ Minnesota, Bioinformat & Computat Biol, Grad Sch, Minneapolis, MN USA

[2] Mayo Clin, Div Hematol, Rochester, MN USA

[3] Mayo Clinic, T Cell Engn, Rochester, MN USA

[4] Mayo Clin, Biomed Stat & Informat, Rochester, MN USA

[5] Mayo Clin, Ctr Individualized Med, Rochester, MN USA

[6] Humanigen, Brisbane, CA USA

[7] Mayo Clin, Grad Sch Biomed Sci, Rochester, MN USA

[8] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA

[9] Mayo Clin, Div Pediat Hematol Oncol, Rochester, MN USA

[10] Mayo Clin, Dept Neurol, Rochester, MN USA

[11] Mayo Clin, Dept Mol Med, Rochester, MN USA

[12] Mayo Clin, Dept Immunol, Rochester, MN USA

来源：

关键词：

D O I：

10.1182/blood-2019-129349

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

3868

引用

页数：4