Gold Nanorods, DNA Origami, and Porous Silicon Nanoparticle-functionalized Biocompatible Double Emulsion for Versatile Targeted Therapeutics and Antibody Combination Therapy

被引：63

作者：

Kong, Feng ^{[1
,7
]}

Zhang, Hongbo ^{[1
,2
,3
]}

Qu, Xiangmeng ^{[1
,2
,4
]}

Zhang, Xu ^{[2
,5
]}

Chen, Dong ^{[2
]}

Ding, Ruihua ^{[2
]}

Makila, Ermei ^{[6
]}

Salonen, Jarno ^{[6
]}

Santos, Helder A. ^{[3
]}

Hai, Mingtan ^{[1
,2
]}

机构：

[1] Univ Sci & Technol Beijing, Sch Mat Sci & Engn, Beijing Key Lab Funct Mat Mol & Struct Construct, Beijing 100083, Peoples R China

[2] Harvard Univ, Harvard John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA

[3] Univ Helsinki, Fac Pharm, Div Pharmaceut Chem & Technol, FI-00014 Helsinki, Finland

[4] East China Normal Univ, Sch Chem & Mol Engn, 500 Dongchuan Rd, Shanghai 200241, Peoples R China

[5] Cape Breton Univ, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada

[6] Univ Turku, Dept Phys, Lab Ind Phys, FI-20014 Turku, Finland

[7] GRIKIN Adv Mat Co Ltd, 33 Chaoqian Rd, Beijing 102200, Peoples R China

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 46期

基金：

加拿大健康研究院; 欧洲研究理事会; 芬兰科学院;

关键词：

WATER-SOLUBLE DRUGS; TRIGGERED RELEASE; ANTICANCER DRUGS; CANCER-THERAPY; ORAL DELIVERY; CO-DELIVERY; RESISTANCE; ENCAPSULATION; FABRICATION; CARRIER;

D O I：

10.1002/adma.201602763

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold nanorods, DNA origami, and porous silicon nanoparticle-functionalized biocompatible double emulsion are developed for versatile molecular targeted therapeutics and antibody combination therapy. This advanced photothermal responsive all-in-one biocompatible platform can be easily formed with great therapeutics loading capacity for different cancer treatments with synergism and multidrug resistance inhibition, which has great potential in advancing biomedical applications.

引用

页码：10195 / 10203

页数：9

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