IL-1 and T helper immune responses

被引：124

作者：

Santarlasci, Veronica ^{[1
]}

Cosmi, Lorenzo ^{[1
]}

Maggi, Laura ^{[1
]}

Liotta, Francesco ^{[1
]}

Annunziato, Francesco ^{[1
]}

机构：

[1] Univ Florence, Dept Expt & Clin Med, I-50134 Florence, Italy

来源：

FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷

关键词：

Th17; cells; Th2; Th1; non-classic; IL-1RI and T cells; IL-1 and T cells; HUMAN TH17 CELLS; RHEUMATOID-ARTHRITIS; HUMAN TH2; TGF-BETA; INTERLEUKIN-1; EXPRESSION; DIFFERENTIATION; CYTOKINE; PRODUCE; INFLAMMATION;

D O I：

10.3389/fimmu.2013.00182

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4 T cells play a critical role in mediating adaptive immunity to a variety of pathogens as well as in tumor immunity. If not adequately regulated, CD4 T cells can be also involved in autoimmunity, asthma, and allergic responses. DuringTCR activation in a particular cytokine milieu, naive CD4T cells may differentiate into one of several lineages of T helper (Th) cells, including Th1, Th2, and Th17, as defined by their pattern of cytokine production and function. IL-1, the prototypic proinflammatory cytokine, has been shown to influence growth and differentiation of immunocompetent lymphocytes. The differential expression of IL-1 RI on human CD4 T cell subsets confers distinct capacities to acquire specific effector functions. In this review, we summarize the role of IL-1 on CD4T cells, in terms of differentiation, activation, and maintenance or survival.

引用

页数：7

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