Relation between neurohormonal activation and enhanced ventilatory response to exercise in patients with chronic congestive heart failure

被引：8

作者：

Kinugawa, T ^{[1
]}

Tomikura, Y ^{[1
]}

Ogino, K ^{[1
]}

Osaki, S ^{[1
]}

Kato, M ^{[1
]}

Igawa, O ^{[1
]}

Hisatome, I ^{[1
]}

Shigemasa, C ^{[1
]}

机构：

[1] Tottori Univ, Fac Med, Dept Internal Med 1, Div Cardiol, Yonago, Tottori 6838504, Japan

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2002年 / 89卷 / 05期

关键词：

D O I：

10.1016/S0002-9149(01)02306-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The slope of the relation between minute ventilation and carbon dioxide output (VE/VCO2 slope) has been proposed as a parameter for evaluating ventilatory response to exercise. (1,2) Enhanced ventilatory response to exercise with a steeper VE/VCO2 slope has been shown in patients with chronic congestive heart failure (CHF).(3,4)Previous studies have demonstrated that heart failure patients with an enhanced ventilatory response to exercise have exercise intolerance,(4) abnormal hemodynamics,(3,5) augmented chemorcceptor sensitivity,(6) and poor prognosis.(7,8) Neurohormonal activation is a hallmark of patients with CHF and relates importantly to the pathophysiology of heart failure.(9) Therefore, we predict that patients with enhanced ventilatory response to exercise are those with higher neurohormonal activation, but these observations have not been clearly demonstrated. Moreover, the relation between the enhanced ventilatory response to exercise and multiple neurohormonal factors remains to be determined in patients with CHF. The aim of this study was to assess whether neurohormonal activation is a predictor of VE/VCO2 Slope in patients with mild to moderate CHF.

引用

页码：604 / +

页数：5

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