Application of Anti-Inflammatory Agents in Prostate Cancer

被引：22

作者：

Hatano, Koji ^{[1
]}

Fujita, Kazutoshi ^{[1
,2
]}

Nonomura, Norio ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Urol, Suita, Osaka 5650871, Japan

[2] Kindai Univ, Fac Med, Dept Urol, Osakasayama, Osaka 5898511, Japan

来源：

JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 08期

基金：

日本学术振兴会;

关键词：

inflammation; prostate cancer; tumor microenvironment; macrophage; myeloid-derived suppressor cell; chemoprevention; aspirin; metformin; statin; immunotherapy; TUMOR-ASSOCIATED MACROPHAGES; REGULATORY T-CELLS; RANDOMIZED CONTROLLED-TRIAL; DIETARY INFLAMMATORY INDEX; INFILTRATING MYELOID CELLS; SUPPRESSOR-CELLS; STATIN USE; MONOCLONAL-ANTIBODY; DOUBLE-BLIND; INTRAEPITHELIAL NEOPLASIA;

D O I：

10.3390/jcm9082680

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic inflammation is a major cause of human cancers. The environmental factors, such as microbiome, dietary components, and obesity, provoke chronic inflammation in the prostate, which promotes cancer development and progression. Crosstalk between immune cells and cancer cells enhances the secretion of intercellular signaling molecules, such as cytokines and chemokines, thereby orchestrating the generation of inflammatory microenvironment. Tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) play pivotal roles in inflammation-associated cancer by inhibiting effective anti-tumor immunity. Anti-inflammatory agents, such as aspirin, metformin, and statins, have potential application in chemoprevention of prostate cancer. Furthermore, pro-inflammatory immunity-targeted therapies may provide novel strategies to treat patients with cancer. Thus, anti-inflammatory agents are expected to suppress the "vicious cycle" created by immune and cancer cells and inhibit cancer progression. This review has explored the immune cells that facilitate prostate cancer development and progression, with particular focus on the application of anti-inflammatory agents for both chemoprevention and therapeutic approach in prostate cancer.

引用

页码：1 / 27

页数：27

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