Zaccai neutron resilience and site-specific hydration dynamics in a globular protein

被引：6

作者：

Miao, Yinglong ^{[1
,2
]}

Hong, Liang ^{[1
,2
]}

Yi, Zheng ^{[1
,2
]}

Smith, Jeremy C. ^{[1
,2
]}

机构：

[1] Univ Tennessee, Oak Ridge Natl Lab, Ctr Biophys Mol, Oak Ridge, TN 37831 USA

[2] Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN 37996 USA

来源：

EUROPEAN PHYSICAL JOURNAL E | 2013年 / 36卷 / 07期

基金：

美国能源部;

关键词：

PANCREATIC TRYPSIN-INHIBITOR; SCATTERING ANALYSIS; MOLECULAR-DYNAMICS; CYTOCHROME P450CAM; BACTERIORHODOPSIN; TEMPERATURE; SIMULATION; MYOGLOBIN; FLEXIBILITY; TRANSITION;

D O I：

10.1140/epje/i2013-13072-5

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A discussion is presented of contributions of the Zaccai group to the understanding of flexibility in biological macromolecules using dynamic neutron scattering. The concept of resilience as introduced by Zaccai is discussed and investigated using molecular dynamics simulation on camphor-bound cytochrome P450. The resilience of hydrophilic residues is found to be more strongly affected by hydration than that of hydrophobic counterparts. The hydration-induced softening of protein propagates from the surface into the dry core. Moreover, buried hydrophilic residues behave more like those exposed on the protein surface, and are different from their hydrophobic counterparts.

引用

页数：6

共 30 条

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