Influence of tumour micro-environment heterogeneity on therapeutic response

被引：2138

作者：

Junttila, Melissa R. ^{[1
]}

de Sauvage, Frederic J. ^{[1
]}

机构：

[1] Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA

来源：

NATURE | 2013年 / 501卷 / 7467期

关键词：

ENDOTHELIAL GROWTH-FACTOR; ANTI-VEGF THERAPY; METASTATIC COLORECTAL-CANCER; SPONTANEOUS MAMMARY-TUMORS; RANDOMIZED PHASE-II; BREAST-CANCER; LUNG-CANCER; CHEMOTHERAPY RESPONSE; MICROVESSEL DENSITY; STROMA PROMOTES;

D O I：

10.1038/nature12626

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tumour formation involves the co-evolution of neoplastic cells together with extracellular matrix, tumour vasculature and immune cells. Successful outgrowth of tumours and eventual metastasis is not determined solely by genetic alterations in tumour cells, but also by the fitness advantage such mutations confer in a given environment. As fitness is context dependent, evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount. The dynamic tumour topography varies drastically even throughout the same lesion. Heterologous cell types within tumours can actively influence therapeutic response and shape resistance.

引用

页码：346 / 354

页数：9

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