The relationship between postmenopausal women's sclerostin levels and their bone density, age, body mass index, hormonal status, and smoking and consumption of coffee and dairy products

被引:19
作者
Kalem, Muberra Namli [1 ]
Kalem, Ziya [2 ]
Akgun, Nilufer [1 ]
Bakirarar, Batuhan [3 ]
机构
[1] Turgut Ozal Univ, Dept Obstet & Gynecol, Fac Med, Ankara, Turkey
[2] Gurgan Clin IVF & Women Hlth Ctr, Ankara, Turkey
[3] Ankara Univ, Dept Biostat, Fac Med, Ankara, Turkey
关键词
Sclerostin; Body mass index; Bone mineral density; Smoking; Coffee; Dairy products; SERUM SCLEROSTIN; VASCULAR CALCIFICATION; PARATHYROID-HORMONE; OSTEOPOROSIS; IMPACT;
D O I
10.1007/s00404-017-4288-x
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
To investigate the relationship between postmenopausal women's sclerostin levels and bone density and the factors that may affect this relationship. 135 postmenopausal patients' ages, BMIs, hormonal statuses, BMD values, and smoking, and consumption of coffee and dairy products were compared with their sclerostin levels. No statistical relationship was found between sclerostin level and age in the group with osteoporosis (p = 0.204, r = -0.305). There was a positive, high-level relationship between sclerostin levels and BMI in the osteoporosis group and it was found to be statistically significant (p < 0.001, r = 0.786). No statistical relationship was found between sclerostin level and age in the non-osteoporosis group with (p = 0.496, r = -0.88). There was a positive, moderate relationship between sclerostin levels and BMI in the non-osteoporosis group and it was found to be statistically significant (p < 0.001, r = 0.505). No statistically significant relationship could be found between sclerostin levels and vitamin D (p = 0.723), PTH (p = 0.112), FSH (p = 0.795), E-2 (p = 0.627), TSH (p = 0.517), T-3 (p = 0.788), and T-4 (p = 0.664) blood levels. No significant difference was found among the groups formed by smoking, consumption of coffee and milk, and dairy products, either (p = 0.405; p = 0.626; p = 0.234, respectively). It was monitored that sclerostin's negative effect observed on BMD scores was independent from age; however, it had a positive correlation with BMI. As blood sclerostin levels increase, bone mineral density decreases. This negative effect of sclerostin on bone density increases as BMI increases, too. Effects of sclerostin levels on bone density are independent from age, and they are not affect by levels of vitamin D: PTH, FSH, E-2 and thyroid hormones, and daily activities, such as smoking and consumption of coffee and milk and dairy products, either.
引用
收藏
页码:785 / 793
页数:9
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