Ageing, oxidative stress and cancer: paradigms in parallax

被引：211
作者：
Benz, Christopher C. [1 ]
Yau, Christina [1 ]
机构：
[1] Buck Inst Age Res, Novato, CA 94945 USA
来源：
NATURE REVIEWS CANCER | 2008年 / 8卷 / 11期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrc2522
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Two paradigms central to geroscience research are that aging is associated with increased oxidative stress and increased cancer risk. Therefore, it could be deduced that cancers arising with ageing will show evidence of increased oxidative stress. Recent studies of gene expression in age-controlled breast cancer cases indicate that this deduction is false, posing parallax views of these two paradigms, and highlighting the unanswered question: does ageing cause or simply permit cancer development?
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收藏
页码：875 / 879
页数：5
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