Body mass does not affect the remission of psoriatic arthritis patients on anti-TNF-α therapy

被引:25
作者
Iannone, F. [1 ]
Fanizzi, R. [1 ]
Scioscia, C. [1 ]
Anelli, M. G. [1 ]
Lapadula, G. [1 ]
机构
[1] Univ Bari, Sch Med, Rheumatol Unit, I-70121 Bari, Italy
关键词
RHEUMATOID-ARTHRITIS; RESPONSE CRITERIA; OBESITY;
D O I
10.3109/03009742.2012.715186
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: There is evidence that fat tissue may influence the response to therapy in patients with arthritis. The aim of this study was to assess whether the body mass index (BMI) affects rates of clinical remission in patients with psoriatic arthritis (PsA) treated with anti-tumour necrosis factor (TNF)-alpha biological drugs. Method: We retrospectively studied 135 patients with active peripheral PsA (45 obese, 47 overweight, and 43 normal-weight). Baseline BMI was correlated with the clinical response to adalimumab, etanercept, or infliximab. After 36 months (median, range 6-79) of treatment, disease remission rates were assessed using the Disease Activity Score in 28 joints (DAS28) or the Simplified Disease Activity Index (SDAI). Possible predictors of clinical outcomes were assessed by multivariate analysis. Results: At baseline, BMI was significantly correlated only with the Health Assessment Questionnaire (HAQ) score (r = 0.21, p = 0.02) and not with disease activity. BMI did not predict disease remission or changes in HAQ score following anti-TNF-alpha therapy. Obese patients showed a significantly higher HAQ score and took significantly lower doses of prednisone than normal-weight or overweight patients, but their disease remission rates on the DAS28 (37%) or the SDAI (21%) were not significantly different from those of the other two groups (44% and 21%, respectively), regardless of the TNF-alpha inhibitor prescribed. Conclusions: In our retrospective analysis, disease activity and clinical response to anti-TNF-alpha therapy in PsA do not seem to be affected by BMI. Further prospective studies are needed to confirm these preliminary results.
引用
收藏
页码:41 / 44
页数:4
相关论文
共 14 条
[1]   Correlation between BMI and PASI in patients affected by moderate to severe psoriasis undergoing biological therapy [J].
Bardazzi, F. ;
Balestri, R. ;
Baldi, E. ;
Antonucci, A. ;
De Tommaso, S. ;
Patrizi, A. .
DERMATOLOGIC THERAPY, 2010, 23 :S14-S19
[2]   Obesity and psoriasis: From the Medical Board of the National Psoriasis Foundation [J].
Bremmer, Samuel ;
Van Voorhees, Abby S. ;
Hsu, Sylvia ;
Korman, Neil J. ;
Lebwohl, Mark G. ;
Young, Melodie ;
Bebo, Bruce F., Jr. ;
Blauvelt, Andrew .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2010, 63 (06) :1058-1069
[3]  
Cassano N, 2008, J BIOL REG HOMEOS AG, V22, P233
[4]   Impact of body mass index on retention rates of anti-TNF-alfa drugs in daily practice for psoriasis [J].
Di Lernia, Vito ;
Tasin, Laura ;
Pellicano, Riccardo ;
Zumiani, Giuseppe ;
Albertini, Giuseppe .
JOURNAL OF DERMATOLOGICAL TREATMENT, 2012, 23 (06) :404-409
[5]   Obesity and the prediction of minimal disease activity: A prospective study in psoriatic arthritis [J].
di Minno, Matteo Nicola Dario ;
Peluso, Rosario ;
Iervolino, Salvatore ;
Lupoli, Roberta ;
Russolillo, Anna ;
Scarpa, Raffaele ;
di Minno, Giovanni .
ARTHRITIS CARE & RESEARCH, 2013, 65 (01) :141-147
[6]   Performance of response criteria for assessing peripheral arthritis in patients with psoriatic arthritis: analysis of data from randomised controlled trials of two tumour necrosis factor inhibitors [J].
Fransen, J. ;
Antoni, C. ;
Mease, P. J. ;
Uter, W. ;
Kavanaugh, A. ;
Kalden, J. R. ;
Van Riel, P. L. C. M. .
ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (10) :1373-1378
[7]   Obesity and Inflammation - Targets for OA Therapy [J].
Iannone, F. ;
Lapadula, G. .
CURRENT DRUG TARGETS, 2010, 11 (05) :586-598
[8]   New remission criteria for RA: 'modern times' in rheumatology-not a silent film, rather a 3D movie [J].
Jacobsson, Lennart T. H. ;
Hetland, Merete Lund .
ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (03) :401-403
[9]   Guideline for anti-TNF-α therapy in psoriatic arthritis [J].
Kyle, S ;
Chandler, D ;
Griffiths, CEM ;
Helliwell, P ;
Lewis, J ;
McInnes, I ;
Oliver, S ;
Symmons, D ;
McHugh, N .
RHEUMATOLOGY, 2005, 44 (03) :390-397
[10]   Relationship of psoriasis severity to obesity using same-gender siblings as controls for obesity [J].
Murray, M. L. ;
Bergstresser, P. R. ;
Adams-Huet, B. ;
Cohen, J. B. .
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2009, 34 (02) :140-144