Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene

被引：17

作者：

Bilbao, G

Contreras, JL

Zhang, HG

Pike, MJ

Overturf, K

Mikheeva, G

Krasnykh, V

Curiel, DT

机构：

[1] Univ Alabama Birmingham, Gene Therapy Ctr, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Transplant Ctr, Dept Surg, Birmingham, AL 35294 USA

[3] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[4] Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL 35294 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 08期

关键词：

D O I：

10.1128/JVI.73.8.6992-7000.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.

引用

页码：6992 / 7000

页数：9

共 82 条

[61] CYT GENE OF ADENOVIRUS-2 AND ADENOVIRUS-5 IS AN ONCOGENE FOR TRANSFORMING FUNCTION IN EARLY REGION E1B AND ENCODES THE E1B 19,000-MOLECULAR-WEIGHT POLYPEPTIDE [J].